Synthesis and preliminary biological assessments of RGD bearing biocompatible telomers

Bioorganic & Medicinal Chemistry Letters
S JasseronB Pucci

Abstract

Work reported herein deals with the synthesis and preliminary biological assessments of a new class of biocompatible telomeric carriers bearing peptidic RGDSK sequences as tumor cell targeting and tyrosine moieties labelled with 125I as in vivo probe. The radioactivity levels obtained in several tissues, after the intravenous injections of these telomers in mice bearing grafted B16 syngenic melanoma showed that the addition of a RGD residue to a telomeric structure confers it an increased affinity for the highly vascularized zone surrounding the tumor.

Citations

Dec 31, 2003·Bioorganic & Medicinal Chemistry Letters·Sandrine PérinoBernard Pucci
Jul 28, 2005·Natural Product Reports·Roberto G S Berlinck, Miriam H Kossuga
Jun 28, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Zhe WangPaul C Ho
Sep 28, 2007·Journal of Biomedical Materials Research. Part a·Zhiyuan HuYangde Zhang
Dec 21, 2006·Chemical Biology & Drug Design·Alan R KatritzkyParul Angrish
Feb 6, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·N Al RifaiN Taulier
Apr 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·K AstafyevaN Taulier

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