Synthesis and preliminary evaluation of the antimicrobial activity of selected 3-benzofurancarboxylic acid derivatives.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jerzy KossakowskiIrena Wolska

Abstract

Halogen derivatives of selected 3-benzofurancarboxylic acids were prepared using 6-acetyl-5-hydroxy-2-methyl-3-benzofuranocarboxylic acid as starting material. (1)H-NMR spectra were obtained for all of the synthesized structures, and for compound VI, an X-ray crystal structure was also obtained. All derivatives were tested for antimicrobial activity against a selection of Gram-positive cocci, Gram-negative rods and yeasts. Three compounds, III, IV, and VI, showed antimicrobial activity against Gram-positive bacteria (MIC 50 to 200 microg/mL). Compounds VI and III exhibited antifungal activity against the Candida strains C. albicans and C. parapsilosis (MIC-100 microg/mL).

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Citations

Oct 1, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nassir N Al-MohammedAidil Abdul Hamid
May 21, 2014·Natural Product Research·Aamer Saeed, Muhammad Qasim
Apr 24, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wen GuZhuhui Chen
Nov 23, 2018·Anti-cancer Agents in Medicinal Chemistry·Karolina Królewska-GolińskaBarbara Nawrot
Aug 16, 2012·The Journal of Pharmacology and Experimental Therapeutics·Elzbieta HejchmanWilliam E Courchesne
Jan 1, 2013·Monatshefte für chemie·Kinga OstrowskaDorota Maciejewska
Apr 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariola NapiórkowskaBarbara Nawrot

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Methods Mentioned

BETA
X-ray
nuclear magnetic resonance
column chromatography

Software Mentioned

SHELXS97
Mercury
SHELXL97

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