Synthesis and production of unsaturated and polyunsaturated fatty acids in yeast: current state and perspectives

Applied Microbiology and Biotechnology
Hiroshi Uemura

Abstract

Recently, many genes involved in the formation of unsaturated and polyunsaturated fatty acids (PUFAs) were isolated. In most cases, their activities were confirmed by expressing them in the well-studied model organism Saccharomyces cerevisiae because its fatty acid compositions are very simple and it does not contain PUFAs. Taking advantage of its genetic tractability and increasing wealth of accessible data, many groups are attempting to produce various useful fatty acids in the model yeasts, mainly in S. cerevisiae. This review describes typical such examples including a very recent study on the expression of a fatty acid hydroxylase gene in fission yeast Schizosaccharomyces pombe. Furthermore, the impact of the genetically engineered alteration of fatty acid composition on the stress tolerance is presented because unsaturated fatty acids have crucial roles in membrane fluidity and signaling processes. Lastly, recent attempts at increasing lipid content in S. cerevisiae are discussed.

References

Jun 26, 1978·Archives of Microbiology·D S ThomasA H Rose
Feb 1, 1979·Lipids·K J StoneG P McNicol
Jan 1, 1986·Critical Reviews in Microbiology·G P Casey, W M Ingledew
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M Sinensky
Sep 15, 1995·European Journal of Biochemistry·P SperlingE Heinz
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·F J van de LooC Somerville
Jul 1, 1993·Trends in Biotechnology·C Ratledge
Oct 1, 1993·Plant Physiology·N S YadavK L Stecca
Feb 1, 1993·Current Opinion in Obstetrics & Gynecology·R E Besinger
Jan 1, 1996·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·W V WilliamsR B Zurier
Jul 29, 1998·The Plant Journal : for Cell and Molecular Biology·P BrounC Somerville
Nov 26, 1998·Progress in Lipid Research·D R TocherP A Hodgson
May 14, 1999·Current Opinion in Plant Biology·J A NapierA K Stobart
Jun 5, 1999·Current Opinion in Plant Biology·J Ohlrogge
Aug 17, 1999·Annual Review of Nutrition·P BrounC Somerville
Sep 16, 1999·Biochemical and Biophysical Research Communications·S PassornS Cheevadhanarak
Dec 22, 1999·European Journal of Biochemistry·P Bouvier-NavéH Schaller
Jan 5, 2000·The American Journal of Clinical Nutrition·D F Horrobin
Mar 8, 2000·Microbiology and Molecular Biology Reviews : MMBR·S OstergaardJ Nielsen
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·F BeaudoinJ A Napier
Jun 16, 2000·Applied Microbiology and Biotechnology·S KajiwaraO Kobayashi
Jul 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·J M Parker-BarnesP Mukerji
May 16, 2001·The Journal of Biological Chemistry·A M CalvoN P Keller
Feb 23, 2002·Nature·V WoodL Cerrutti
May 15, 2002·Bioscience, Biotechnology, and Biochemistry·Katsuya InagakiOsamu Suzuki

❮ Previous
Next ❯

Citations

Apr 25, 2013·Applied Microbiology and Biotechnology·Yasushi KamisakaMasakazu Yamaoka
Mar 16, 2013·Chemical Reviews·Christine A Rabinovitch-DeereShota Atsumi
Aug 8, 2013·Environmental Science & Technology·Vikram KapoorDavid Wendell
Jul 17, 2015·Critical Reviews in Biotechnology·Kyle V ProbstPraveen V Vadlani
Apr 30, 2013·Biotechnology Journal·Tatiana KlempovaMilan Certik
Sep 14, 2013·FEMS Yeast Research·Izabela Sadowska-BartoszGrzegorz Bartosz
Jun 18, 2016·Applied Microbiology and Biotechnology·Yasushi KamisakaRodrigo Ledesma-Amaro
Jul 26, 2017·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Michal TupecIva Pichová
Jan 27, 2019·Chemistry : a European Journal·Piotr PołczyńskiWojciech Grochala
Aug 5, 2017·Applied Microbiology and Biotechnology·Raphael Hermano Santos DinizWendel Batista da Silveira
Aug 8, 2020·Frontiers in Cellular and Infection Microbiology·Adriana Marcela Celis RamírezHans de Cock
Apr 2, 2020·Frontiers in Bioengineering and Biotechnology·David Calderón-FrancoDavid G Weissbrodt
Jul 30, 2017·Journal of the Science of Food and Agriculture·Nan MengQiu-Hong Pan
Feb 3, 2021·International Journal of Environmental Research and Public Health·Stefano BertacchiPaola Branduardi
Mar 2, 2021·Food Research International·Lethiwe Lynett MbuyaneBenoit Divol
Apr 26, 2019·Metabolic Engineering·Qiang Yan, Brian F Pfleger
Mar 21, 2021·Applied Microbiology and Biotechnology·Lahiru N Jayakody, Yong-Su Jin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.