Abstract
A synthetic process for obtaining high-molecular-weight block copolymers containing poly(lactic-glycolic acid) and poly(ethylene glycol) segments has been established. This process involves the reaction of poly(ethylene glycols) with phosgene, followed by polycondensation of the resulting alpha, omega-bis(chloroformates) with poly(lactic-glycolic acid) oligomers. The copolymers have been characterized for their molecular weight, solubility properties, water absorption and preliminarily thermal behaviour. All evidence points to the conclusion that the process described is a general one, enabling biodegradable polymers to be obtained tailor-made according to specific requirements.
Citations
Mar 25, 1998·Journal of Biomedical Materials Research·S J Sofia, E W Merrill
Jan 27, 2005·Analytical and Bioanalytical Chemistry·Shenguo WangJianzhong Bei
Jan 5, 2008·Bioprocess and Biosystems Engineering·Verónica LassalleMaría Luján Ferreira
Jan 5, 2006·Pharmaceutical Research·Li Yan Qiu, You Han Bae
Aug 1, 1996·Biomaterials·M PencoR Deghenghi
Dec 6, 2001·Advanced Drug Delivery Reviews·N KumarA J Domb
Jul 25, 2003·International Journal of Pharmaceutics·Delphine MallardéRomano Deghenghi
Oct 13, 2009·International Journal of Pharmaceutics·Sing-Muk NgJeong Ok Lim
Nov 22, 2015·Advances in Colloid and Interface Science·Yit Lung Khung, Dario Narducci
Jul 31, 2013·Journal of Biomedical Materials Research. Part a·Bharat Bhushan, Scott R Schricker
Nov 17, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Richard Quesnel, Patrice Hildgen
Mar 20, 2010·Journal of Biomaterials Applications·Frank LudererKatrin Sternberg
Apr 28, 2018·Materials·Yasser H A Hussein, Mohamed Youssry
Jul 29, 1998·Macromolecules·S J SofiaE W Merrill