Synthesis and Properties of Star HPMA Copolymer Nanocarriers Synthesised by RAFT Polymerisation Designed for Selective Anticancer Drug Delivery and Imaging

Macromolecular Bioscience
Petr ChytilTomas Etrych

Abstract

High-molecular-weight star polymer drug nanocarriers intended for the treatment and/or visualisation of solid tumours were synthesised, and their physico-chemical and preliminary in vitro biological properties were determined. The water-soluble star polymer carriers were prepared by the grafting of poly(amido amine) (PAMAM) dendrimers by hetero-telechelic N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers, synthesised by the controlled radical Reversible Addition Fragmentation chain Transfer (RAFT) polymerisation. The well-defined star copolymers with Mw values ranging from 2 · 10(5) to 6 · 10(5) showing a low dispersity (approximately 1.2) were prepared in a high yield. A model anticancer drug, doxorubicin, was bound to the star polymer through a hydrazone bond, enabling the pH-controlled drug release in the target tumour tissue. The activated polymer arm ends of the star copolymer carrier enable a one-point attachment for the targeting ligands and/or a labelling moiety. In this study, the model TAMRA fluorescent dye was used to prove the feasibility of the polymer carrier visualisation by optical imaging in vitro. The tailor-made structure of the star polymer carriers should facilitate the synthesis of targeted polymer-drug ...Continue Reading

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Citations

Feb 20, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tomáš EtrychKarsten Mäder
Sep 28, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jiyuan YangJindřich Kopeček
Dec 13, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Milada ŠírováTomáš Etrych
Dec 23, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sonja DragojevicDrazen Raucher
Aug 15, 2017·Macromolecular Bioscience·Petr ChytilKarel Ulbrich
Oct 21, 2016·Physiological Research·L Kostka, T Etrych
Nov 1, 2018·Physiological Research·L KotrchováT Etrych
Feb 14, 2021·Journal of Personalized Medicine·Petr ChytilTomáš Etrych
Dec 26, 2017·Current Opinion in Colloid & Interface Science·Jiyuan Yang, Jindřich Kopeček
Oct 14, 2019·ACS Biomaterials Science & Engineering·Sara AbasiAnthony Guiseppi-Elie

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