PMID: 590615Nov 1, 1977

Synthesis and release of gonadotropins and their subunits by long-term organ cultures of human fetal hypophyses

Molecular and Cellular Endocrinology
J L PasteelsP Franchimont


From weeks 13 to 26 of fetal life human hypophyses disclosed a constant content of radioimmunoassayable FSH. Although present already before this period, LH content increased considerably at week 17, along with the appearance of free beta-LH. In long-term organ culture experiments such early differentiating pituitaries proved to be endowed with autonomous synthesis and release of FSH and of free alpha-subunit, while LH, beta-LH and TSH declined to very low levels within a few weeks. Supplementation of the medium with LH-RH (12 ng/ml) significantly increased FSH synthesis and release but was not sufficient to sustain production of beta-LH and LH. It is suggested that other factors than LH-RH are required for differentiation of beta-LH biosynthesis and thus for production of LH.


Nov 1, 1975·The American Journal of Anatomy·D C Herbert
Jan 1, 1970·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P K Nakane
Jan 1, 1973·Acta Endocrinologica. Supplementum·F LabrieR Boucher
Nov 1, 1974·The Journal of Clinical Endocrinology and Metabolism·T M Siler-KhodrF C Greenwood
Dec 1, 1971·The Journal of Clinical Endocrinology and Metabolism·J VaitukaitisG T Ross
Sep 1, 1969·Metabolism: Clinical and Experimental·P O KohlerS E Kohler
May 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·S D GailaniW F McLimans
Apr 1, 1971·Endocrinology·F J Morgan, R E Canfield
Nov 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·K W THOMPSONE SCHAPIRO


Nov 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·B LorasJ Bertrand
May 1, 1984·Molecular and Cellular Endocrinology·H E GrotjanB A Keel
Feb 1, 1993·Molecular and Cellular Endocrinology·U MichelJ K Findlay
Apr 1, 1995·In Vitro Cellular & Developmental Biology. Animal·A H BalenM Rose

Related Concepts

Fetal Structures
Follicle Stimulating Hormone
Gestational Age
Organ Culture Techniques
Pituitary Stalk

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