Synthesis and SAR of alpha-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors

Bioorganic & Medicinal Chemistry Letters
Yue-Mei ZhangPaul Jackson

Abstract

A series of novel carboxylic acid-based alpha-sulfone MMP inhibitors have been synthesized and the in vitro enzyme SAR is discussed. A potential binding mode in the active site of the MMP-9 homology model was highlighted. These compounds are potent MMP-9 inhibitors and are selective over MMP-1.

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Citations

Aug 1, 2006·Expert Opinion on Drug Discovery·Thierry Langer, Rémy D Hoffmann
Mar 4, 2021·Journal of Medicinal Chemistry·Rao SongTao Yang

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