PMID: 2125277Dec 17, 1990Paper

Synthesis and secretion of Alzheimer amyloid beta A4 precursor protein by stimulated human peripheral blood leucocytes

FEBS Letters
U MönningK Beyreuther

Abstract

Alzheimer amyloid precursor proteins (APP) are actively secreted by stimulated human peripheral mononuclear blood leucocytes (PMBLs). Induction of APP transcription, translation and secretion was observed with several T cell mitogens but was highest with phytohemagglutinin. The time course of induction is similar to that reported for IL-2 and IL-2 receptor. We suggest that APP may play an important role in the construction of the immunological network and the differentiation of T cells.

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Citations

Feb 1, 1992·Journal of the Neurological Sciences·T PirttiläH Frey
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Nov 3, 2021·Aging Cell·Linbin Dai, Yong Shen

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