Synthesis and secretion of natriuretic peptides in the hypertensive TGR(mREN-2)27 transgenic rat

Hypertension
M MarttilaHeikki Ruskoaho

Abstract

To examine the pathophysiological mechanisms in transgenic rats carrying the murine Ren-2d renin gene, we studied atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) gene expression and secretion in 12-week-old hypertensive TGR(mREN-2)27 and normotensive Sprague-Dawley rats. Hypertension and marked left ventricular hypertrophy in TGR(mREN-2)27 rats were associated with high baseline plasma levels of immunoreactive ANP (148 +/- 18 versus 34 +/- 3 pmol/L, hypertensive versus normotensive rats; P < .001), whereas plasma immunoreactive BNP levels did not differ significantly between the strains (19 +/- 4 versus 12 +/- 3 pmol/L, P = .06). ANP mRNA and immunoreactive ANP levels in the left ventricular endocardial and epicardial layers in TGR(mREN-2)27 rats were about 20 to 40 times higher (P < .001) than those in normotensive rats. There were no statistically significant differences between atrial and ventricular BNP mRNA levels, but left ventricular immunoreactive BNP concentrations were twofold higher in hypertensive TGR(mREN-2)27 than in normotensive rats. Infusion of [Arg8]-vasopressin (0.05 microgram/kg per minute IV, for 2 hours) in normotensive rats produced rapid increases (twofold, P < .05 to .01) in left ve...Continue Reading

References

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Citations

Nov 6, 2003·Regulatory Peptides·Thomas WaltherHolger Stepan
Jul 16, 2013·Biochimica Et Biophysica Acta·Irina A Sergeeva, Vincent M Christoffels
Feb 2, 2018·Journal of Neurosurgical Anesthesiology·Abhijit LeleMonica S Vavilala
Jun 6, 2003·Endocrine Reviews·Heikki Ruskoaho
Mar 2, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Amin ShahSuhn Hee Kim
Feb 6, 2017·European Journal of Heart Failure·Mariann GyöngyösiFaiez Zannad

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