PMID: 11931967Apr 5, 2002Paper

Synthesis and selective tumor targeting properties of water soluble porphyrin-Pt(II) conjugates

Journal of Inorganic Biochemistry
Rita SongYoun Soo Sohn

Abstract

We have designed and synthesized a series of novel water soluble porphyrins and their platinum(II) conjugates, cis-[(Por)Pt(dmso)X], where Por=5-(4-pyridyl)-10,15,20-tris(4-sulfonatophenyl)porphyrin) (PyTPPS) or 5-[4-(3-aminopropyl)pyridiniumyl]-10,15,20-tris(4-sulphonatophenyl)porphyrin (PyTPPS-NPn), X=2Cl, 1,1-cyclobutanedicarboxylic acid, oxalate, or malonate. Their biodistribution in tumor bearing mouse was examined along with their antitumor activity against murine leukemia L1210 cell line. The representative complex 1 exhibited a significant accumulation in tumor tissue with a tumor/muscle ratio of 7 after 24 h post injection. The antitumor activity of the title compounds was marginal (T/C: 95-117%), but it was found that platinum(II) coordination to the porphyrin periphery did not affect the tumor accumulating properties of the porphyrin permitting further derivatization for efficient delivery of the Pt(II) antitumor agent.

References

Jun 1, 1987·Photochemistry and Photobiology·D KesselK D Nantwi
Sep 1, 1996·Photochemistry and Photobiology·R W Boyle, D Dolphin

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Citations

Mar 28, 2003·Bioorganic & Medicinal Chemistry·Yeong-Sang KimYoun-Soo Sohn
Apr 2, 2010·ACS Applied Materials & Interfaces·Rajiv KumarParas N Prasad
Jun 15, 2007·Free Radical Biology & Medicine·Guo-Ping YanSteven E Bottle
Jun 14, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michael Luciano, Christian Brückner
May 24, 2014·Angewandte Chemie·Anu NaikBernhard Spingler
Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Teresa GianferraraEnzo Alessio
Feb 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mirong GuanChunying Shu
Jun 9, 2005·Chemical Reviews·Konrad SzaciłowskiGrazyna Stochel

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