Synthesis and structural-activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents

Bioorganic & Medicinal Chemistry Letters
Tuan P TranRajeshwar Singh

Abstract

A series of 3-hydroxyquinazoline-2,4-diones was synthesized and evaluated for antibacterial activity. This series represents a novel addition to the DNA gyrase inhibitor class of antibacterials. Appropriate substitutions onto the core template yielded compounds with excellent potency against E. coli gyrase and significant in vitro Gram-negative and Gram-positive antibacterial activity.

References

Oct 1, 1990·Antimicrobial Agents and Chemotherapy·N J MoreauX Tabary
Dec 1, 1985·Antimicrobial Agents and Chemotherapy·M A CohenJ M Domagala
Apr 1, 1994·The Journal of Antimicrobial Chemotherapy·J M Domagala
May 1, 1993·Antimicrobial Agents and Chemotherapy·G W KaatzC A Ruble

❮ Previous
Next ❯

Citations

Mar 11, 2005·Expert Opinion on Investigational Drugs·Michael N Alekshun
Aug 19, 2005·Expert Review of Anti-infective Therapy·André Bryskier
Aug 18, 2016·Molecular Diversity·Eduardo EncisoEvangelina Beltrán-López
Jul 19, 2013·Chemical Communications : Chem Comm·Emilie RacineMarc Taillefer
May 6, 2009·Journal of the American Chemical Society·Bassam K AlnaslehMichael Rubin
Jul 13, 2013·The Journal of Organic Chemistry·Joseph E BanningMichael Rubin
Jul 8, 2020·Journal of Medicinal Chemistry·Colin K SkepperAlexey Rivkin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.