Synthesis and structural characterisation of bismuth(III) hydroxamates and their activity against Helicobacter pylori

Dalton Transactions : an International Journal of Inorganic Chemistry
Amita PathakPhilip C Andrews

Abstract

Seven new bismuth(iii) hydroxamate complexes derived from the hydroxamic acids N-methylfurohydroxamic acid (H-MFHA), N-benzoyl-N-phenylhydroxamic acid (H-BPHA), salicylhydroxamic acid (H2-SHA), benzohydroxamic acid (H2-BHA), and acetohydroxamic acid (H2-AHA) have been synthesized and characterized. The complexes formed are either tris-hydroxamato complexes containing only mono-anionic ligands, [Bi(H-SHA)3], [Bi(MFHA)3] and [Bi(BPHA)3]; mixed-anion complexes, [Bi(SHA)(H-SHA)] and [Bi(AHA)(H-AHA)]; and potassium bismuthate complexes, K[Bi(SHA)2] and K[Bi(BHA)2]. The solid-state structure of three complexes has been determined through single crystal X-ray diffraction; [Bi(MFHA)3]2·Me2C[double bond, length as m-dash]O, {[Bi(SHA)(H-SHA)(DMSO)2][Bi(SHA)(H-SHA)(DMSO)]·DMSO}∞ and [Bi(BPHA)3]2·2EtOH. All the complexes and their parent acids were assessed for the bactericidal activity against three strains of Helicobacter pylori (26695, B128 and 251). Of the acids, only acetohydroxamic acid showed any activity at low concentrations (MIC 6.25 μg mL(-1); 83.26 μM) while the others were not toxic below 25 μg mL(-1). In contrast, their bismuth(iii) complexes all showed excellent activity across all three strains (e.g. 0.28 μM for [Bi(H-SHA)3...Continue Reading

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Citations

Apr 9, 2016·The Journal of Organic Chemistry·Lanlan ZhangZhong Jin
Mar 7, 2018·Toxicology and Industrial Health·Yongming LiuLeshuai W Zhang
Jun 18, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·D M KeoganD M Griffith
Jul 3, 2018·Future Medicinal Chemistry·Yih Ching OngPhilip C Andrews
Jun 19, 2018·Chemistry : a European Journal·Melissa V WerrettPhilip C Andrews
Oct 17, 2018·Chemistry : a European Journal·Zhifang GuoPeter Courtney Junk
Sep 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marina A KatkovaSergey Y Ketkov
Jun 28, 2019·The Journal of Organic Chemistry·Orsola BaydounThierry Brotin
Dec 27, 2019·Inorganic Chemistry·Junaid AliViswanathan Baskar
Sep 18, 2021·Chemical Society Reviews·Darren M GriffithHongzhe Sun
Dec 6, 2021·Acta Crystallographica. Section C, Structural Chemistry·Seik Weng Ng

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