Synthesis and structure-activity relationship of N-(3-azabicyclo[3.1.0]hex-6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists

Bioorganic & Medicinal Chemistry Letters
Matteo BiagettiLaura Caberlotto

Abstract

A novel class of small molecule NPY Y5 antagonists based around an azabicyclo[3.1.0]hexane scaffold was identified through modification of a screening hit. Structure-activity relationships and efforts undertaken to achieve a favourable pharmacokinetic profile in rat are described.

References

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Aug 20, 2009·Current Medicinal Chemistry·Bertrand Le Bourdonnec, Lara K Leister
Sep 12, 2009·Expert Opinion on Therapeutic Patents·Nagaaki SatoMakoto Ando

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Citations

May 7, 2011·British Journal of Pharmacology·Ernie YulyaningsihAmanda Sainsbury

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