Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors

Bioorganic & Medicinal Chemistry Letters
Jongkook LeeSung Yun Cho

Abstract

A series of hydroxybenzoxazole derivatives was synthesized, and their c-Met kinase inhibitory activity was evaluated. Described herein is a potent c-Met inhibitor by structural modification of the parent benzoxazole scaffold, with particular focus on the hydroxyl substituent of the benzoxazole moiety.

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Citations

Jan 13, 2016·Archives of Pharmacal Research·Eun-Young KimSung Yun Cho
Dec 7, 2018·Expert Opinion on Drug Discovery·Zhi-Gang SunHai-Liang Zhu
Feb 27, 2020·Organic & Biomolecular Chemistry·Kanchanbala SahooNiranjan Panda
Aug 9, 2019·Anti-cancer Agents in Medicinal Chemistry·Sakineh DadashpourHamid Irannejad
Aug 10, 2017·Oncology Letters·Kyoung Bin YoonSun-Young Han
Apr 9, 2018·Bioorganic & Medicinal Chemistry Letters·Helen V WaldschmidtScott D Larsen
May 25, 2021·Organic & Biomolecular Chemistry·So Won Youn, Cheon-Gyu Cho

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