Synthesis and structure elucidation of new μ-oxamido-bridged dicopper(II) complex with in vitro anticancer activity: A combined study from experiment verification and docking calculation on DNA/protein-binding property

Journal of Photochemistry and Photobiology. B, Biology
Ling ZhuCui-Wei Yan

Abstract

A new oxamido-bridged dicopper(II) complex with formula of [Cu2(deap)(pic)2], where H2deap and pic represent N,N'-bis[3-(diethylamino)propyl]oxamide and picrate, respectively, was synthesized and characterized by elemental analyses, molar conductance measurements, IR and electronic spectral study, and single-crystal X-ray diffraction. The crystal structure analyses revealed that the two copper(II) atoms in the dicopper(II) complex are bridged by the trans-deap(2-) ligand with the distances of 5.2116(17)Å, and the coordination environment around the copper(II) atoms can be described as a square-planar geometry. Hydrogen bonding and π-π stacking interactions link the dicopper(II) complex into a three-dimensional infinite network. The DNA/protein-binding properties of the complex are investigated by molecular docking and experimental assays. The results indicate that the dicopper(II) complex can interact with HS-DNA in the mode of intercalation and effectively quench the intrinsic fluorescence of protein BSA by 1:1 binding with the most possible binding site in the proximity of Trp134. The in vitro anticancer activities suggest that the complex is active against the selected tumor cell lines, and IC50 values for SMMC-7721 and HepG...Continue Reading

References

Jun 1, 1996·Current Opinion in Structural Biology·T Lengauer, M Rarey
Oct 23, 1997·Journal of Inorganic Biochemistry·L Jin, P Yang
Dec 26, 2001·Chemical Reviews·E Wong, C M Giandomenico
Mar 26, 2004·Journal of Inorganic Biochemistry·Arturo SilvestriSalvatore Tumminello
Jul 20, 2006·DNA and Cell Biology·Herman MalongaHeidar-Ali Tajmir-Riahi
Dec 25, 2007·Acta Crystallographica. Section A, Foundations of Crystallography·George M Sheldrick
Mar 4, 2009·Inorganic Chemistry·Ashis K PatraAkhil R Chakravarty
Apr 29, 2009·Journal of Computational Chemistry·Garrett M MorrisArthur J Olson
May 28, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Brenno A D Neto, Alexandre A M Lapis
Sep 2, 2009·The Journal of Physical Chemistry. B·Arturo RobertazziJan Reedijk
Mar 27, 2010·Current Pharmaceutical Design·Michael FrezzaQ Ping Dou
Sep 29, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Dawei LuRutao Liu
Feb 16, 2012·Inorganic Chemistry·Peter CombaArkadius Waleska
May 23, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Gianni SavaAlberta Bergamo
Sep 21, 2012·Acta Crystallographica. Section D, Biological Crystallography·Anna Bujacz
May 3, 2013·Chemical Communications : Chem Comm·Nicolas P E Barry, Peter J Sadler
Jun 4, 2013·Journal of Photochemistry and Photobiology. B, Biology·Bao-Li FeiWei-Yin Sun
Oct 10, 2013·Chemical Reviews·Carlo SantiniCristina Marzano
Nov 11, 2014·Molecular BioSystems·Sumit Kumar ChaturvediRizwan Hasan Khan

❮ Previous
Next ❯

Related Concepts

© 2022 Meta ULC. All rights reserved