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Synthesis and studies on the effect of 2-thiouridine and 4-thiouridine on sugar conformation and RNA duplex stability

Nucleic Acids Research

Mar 15, 1997

R K Kumar, D R Davis

PMID: 9092639

Abstract

In order to understand the effect of 2-thiouridine (s2U) substitution on RNA structure and the potential for stabilization of tRNA codon-anticodon interactions through s2U-34 modification, a pentamer RNA sequence, Gs2UUUC, was synthesized and characterized by NMR spectroscopy. The singl...read more

Mentioned in this Paper

Thermodynamics
In Vivo NMR Spectroscopy
Sense Codon
Thiouridine
Lysine-Specific tRNA
Oligoribonucleotides
Anticodon
RNA
Paper Details
References
  • References30
  • Citations60
123
  • References30
  • Citations60
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Synthesis and studies on the effect of 2-thiouridine and 4-thiouridine on sugar conformation and RNA duplex stability

Nucleic Acids Research

Mar 15, 1997

R K Kumar, D R Davis

PMID: 9092639

DOI:

Abstract

In order to understand the effect of 2-thiouridine (s2U) substitution on RNA structure and the potential for stabilization of tRNA codon-anticodon interactions through s2U-34 modification, a pentamer RNA sequence, Gs2UUUC, was synthesized and characterized by NMR spectroscopy. The singl...read more

Mentioned in this Paper

Thermodynamics
In Vivo NMR Spectroscopy
Sense Codon
Thiouridine
Lysine-Specific tRNA
Oligoribonucleotides
Anticodon
RNA

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Paper Details
References
  • References30
  • Citations60
123
  • References30
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