Synthesis and systematic review of reported neonatal SARS-CoV-2 infections

Nature Communications
Roberto RaschettiDaniele De Luca

Abstract

A number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have been reported in neonates. Here, we aim to clarify the transmission route, clinical features and outcomes of these infections. We present a meta-analysis of 176 published cases of neonatal SARS-CoV-2 infections that were defined by at least one positive nasopharyngeal swab and/or the presence of specific IgM. We report that 70% and 30% of infections are due to environmental and vertical transmission, respectively. Our analysis shows that 55% of infected neonates developed COVID-19; the most common symptoms were fever (44%), gastrointestinal (36%), respiratory (52%) and neurological manifestations (18%), and lung imaging was abnormal in 64% of cases. A lack of mother-neonate separation from birth is associated with late SARS-CoV-2 infection (OR 4.94 (95% CI: 1.98-13.08), p = 0.0002; adjusted OR 6.6 (95% CI: 2.6-16), p < 0.0001), while breastfeeding is not (OR 0.35 (95% CI: 0.09-1.18), p = 0.10; adjusted OR 2.2 (95% CI: 0.7-6.5), p = 0.148). Our findings add to the literature on neonatal SARS-CoV-2 infections.

References

Apr 11, 2013·Journal of Clinical Epidemiology·Jeffrey C AndrewsGordon Guyatt
Sep 17, 2013·Journal of Clinical Epidemiology·Joel J GagnierUNKNOWN CARE Group
Nov 5, 2013·Virulence·Birju A Shah, James F Padbury
Jul 28, 2015·JAMA Pediatrics·Wade Harrison, David Goodman
Jul 9, 2017·The Lancet. Respiratory Medicine·Daniele De LucaPeter C Rimensberger
Feb 9, 2018·BMJ Evidence-based Medicine·Mohammad Hassan MuradFateh Bazerbachi
Nov 15, 2019·The Pediatric Infectious Disease Journal·David E BloomAndrew Stawasz
Feb 8, 2020·The Pediatric Infectious Disease Journal
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 3, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Xiaotong WangXinghua Shen
Mar 11, 2020·The Lancet Child & Adolescent Health·Daniele De Luca
Mar 11, 2020·Annals of Translational Medicine·Laishuan WangUNKNOWN Working Committee on Perinatal and Neonatal Management for the Prevention and Control of the 2019 Novel Coronavirus Infectio
Mar 19, 2020·The New England Journal of Medicine·Xiaoxia LuUNKNOWN Chinese Pediatric Novel Coronavirus Study Team
Mar 30, 2020·The Lancet Global Health·Maimuna S Majumder, Kenneth D Mandl
Apr 3, 2020·Infectious Diseases·Mojtaba Kamali AghdamKambiz Eftekhari
Apr 5, 2020·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Clara Alonso DíazCarmen Rosa Pallás Alonso
Apr 9, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Enrico M FerrazziGianluigi Gargantini
Apr 12, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Prakesh S ShahAri Bitnun
Apr 17, 2020·Nature Medicine·Xi HeGabriel M Leung
Apr 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mi Seon HanEun Hwa Choi
Apr 18, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michal ParetAdam J Ratner
Apr 19, 2020·American Journal of Perinatology·Maria Claudia AlzamoraMauricio La Rosa
Apr 21, 2020·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Guglielmo SalvatoriAndrea Campana
Apr 23, 2020·The New England Journal of Medicine·Alvaro Coronado MunozKonstantinos Boukas
Apr 25, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Andrea CarossoChiara Benedetto
May 1, 2020·JAMA : the Journal of the American Medical Association·David BaudLéo Pomar
May 3, 2020·American Journal of Perinatology·Danilo BuonsensoPiero Valentini
May 4, 2020·American Journal of Obstetrics and Gynecology·Sedigheh HantoushzadehKjersti Aagaard
May 6, 2020·Pediatrics·Mariateresa SinelliMaria Luisa Ventura
May 11, 2020·The Lancet Child & Adolescent Health·Fiammetta PiersigilliOlivier Danhaive
May 11, 2020·British Journal of Anaesthesia·Mingyang SunJiaqiang Zhang
May 14, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Silvia Garazzino The Italian Sitip-Sip Pediatric Infection Study Group
May 15, 2020·The Pediatric Infectious Disease Journal·Pauline MeslinNeila Zemouri
May 15, 2020·The Pediatric Infectious Disease Journal·Norbert LorenzKonstantin Gröber
May 15, 2020·American Journal of Obstetrics and Gynecology·Gabriela N AlgarrobaAnthony M Vintzileos
May 16, 2020·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Maksim KirtsmanPrakesh S Shah
May 20, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Charles EgloffPierre Roques

❮ Previous
Next ❯

Citations

Dec 1, 2020·Acta Paediatrica·Aysha IqbalTopun Austin
Jan 7, 2021·Maternal & Child Nutrition·Laura N HaiekMelissa Bartick
Jan 5, 2021·Frontiers in Medicine·Md Mohaimenul IslamYu-Chuan Jack Li
Jan 13, 2021·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Gonzalo Solís-GarcíaManuel Sánchez-Luna
Jan 24, 2021·The Lancet Child & Adolescent Health·Florian GötzingerUNKNOWN ptbnet COVID-19 Study Group
Feb 2, 2021·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A J VivantiA Benachi
Feb 11, 2021·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Melissa C BartickLori Feldman-Winter
Dec 18, 2020·Frontiers in Pediatrics·Leon R MitoulasSeverine Liabat
Feb 2, 2021·Frontiers in Pediatrics·Binzhi TangMaojun Li
Feb 23, 2021·Paediatrics and International Child Health·Marlos Melo MartinsAntônio José Ledo Alves da Cunha
Mar 2, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Peilin ZhangSanford Lederman
Nov 14, 2020·European Journal of Pediatrics·Venkateshwarlu VardhelliSusanta Kumar Badatya
Jan 27, 2021·The Journal of Clinical Investigation·Fulvia Milena CribiùPaolo Nuciforo
Mar 16, 2021·Lupus·Hieronymus Tw SmeeleRadboud Jem Dolhain
Mar 20, 2021·World Journal of Pediatrics : WJP·Kai YanLing-Kong Zeng
Feb 2, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Serdar BekenAyse Korkmaz
Apr 1, 2021·European Journal of Pediatrics·Vana SpoulouAthanasios Michos
Apr 7, 2021·Journal of Tropical Pediatrics·Jorge L Alvarado-SocarrasAlfonso J Rodriguez-Morales
Apr 9, 2021·Pediatric Research·Maria Elena CavicchioloEugenio Baraldi
Apr 8, 2021·Nature Reviews. Microbiology·Tim FlerlageStacey Schultz-Cherry
Apr 30, 2021·JAMA : the Journal of the American Medical Association·Mikael NormanOlof Stephansson
May 2, 2021·NeoReviews·Deepika SankaranSatyan Lakshminrusimha
May 14, 2021·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Hannah G JunckerBritt J van Keulen
Mar 26, 2021·Journal of Medical Virology·María Y Valdespino-VázquezClaudine Irles
Jun 6, 2021·Neonatal Network : NN·Susan M Ludington-HoeKaren D'Apolito
Jun 3, 2021·Pathogens·Cinzia Auriti On Behalf Of The Study Group Of Neonatal Infectious Diseases
Jun 3, 2021·International Journal of Environmental Research and Public Health·Maria Giulia ContiGianluca Terrin
May 22, 2021·Journal of Infection and Public Health·Abdulrahman Al-MataryFaisal K Aldandan
Jun 11, 2021·The American Journal of Pathology·Arthur ColsonFrédéric Debiève
Jun 9, 2021·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Paz González RodríguezUNKNOWN en representación del Grupo de Trabajo de Pediatría Basada en la Evidencia de la AEP y AEPap
Jul 3, 2021·Journal of Clinical Medicine·Gilbert G G Donders On The Behalf Of The Covid-Isidog Guideline Group
Jun 22, 2021·Frontiers in Sociology·Kim Gutschow, Robbie Davis-Floyd
Jun 15, 2021·Frontiers in Immunology·Patricia Zadorosnei RebutiniLucia de Noronha

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

MedCalc
Mayo Evidence - Based Practice Centre tool
Mayo Evidence - Based Practice Center
Excel
Zotero

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Review for Medical and Pharmacological Sciences
Y-X BaiK-W Ma
Frontiers in Pediatrics
Ana Cristina Simões E Silva, Caio Ribeiro Vieira Leal
© 2021 Meta ULC. All rights reserved