PMID: 26325575DOI: 10.1039/c5dt01618eSep 2, 2015Paper
Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates
Dalton Transactions : an International Journal of Inorganic Chemistry
Tiankun ZhaoThomas Huhn
Abstract
A series of novel sulfonamide substituted heteroleptic salan titanium(IV)-bis-chelates complexed to 2,6-pyridinedicarboxylic acid were synthesized, structurally characterized and evaluated for their anticancer activity against two human carcinoma cell lines. All cytotoxic complexes showed complete inhibition of cell growth at active concentration, two complexes based on pyrrolidine and azepane substituted sulfonamides displayed IC50 values below 1.7 μM and are more cytotoxic than cisplatin in both tested cell lines. The azepane substituted complex [L3Ti(dipic)] exhibited excellent activity with an IC50 value of 0.5 ± 0.1 μM in Hela S3 and 1.0 ± 0.1 μM in Hep G2.
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Jun 21, 2016·Chemistry : a European Journal·Sigalit MekerEdit Y Tshuva
Jul 28, 2016·Chemical Communications : Chem Comm·Fabian SchneiderThomas Huhn
Nov 20, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Georges KhalilPierre Mobian
May 30, 2021·Journal of Inorganic Biochemistry·Gilad NahariEdit Y Tshuva
Aug 8, 2021·Journal of Inorganic Biochemistry·Rosario SerranoMaria Jose Ruiz
Aug 19, 2020·Inorganic Chemistry·Matthieu Scarpi-LuttenauerPierre Mobian
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