Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates

Dalton Transactions : an International Journal of Inorganic Chemistry
Tiankun ZhaoThomas Huhn

Abstract

A series of novel sulfonamide substituted heteroleptic salan titanium(IV)-bis-chelates complexed to 2,6-pyridinedicarboxylic acid were synthesized, structurally characterized and evaluated for their anticancer activity against two human carcinoma cell lines. All cytotoxic complexes showed complete inhibition of cell growth at active concentration, two complexes based on pyrrolidine and azepane substituted sulfonamides displayed IC50 values below 1.7 μM and are more cytotoxic than cisplatin in both tested cell lines. The azepane substituted complex [L3Ti(dipic)] exhibited excellent activity with an IC50 value of 0.5 ± 0.1 μM in Hela S3 and 1.0 ± 0.1 μM in Hep G2.

References

Jun 1, 1979·Angewandte Chemie·H Köpf, P Köpf-Maier
Apr 26, 1969·Nature·B RosenbergV H Mansour
Jan 1, 1994·European Journal of Clinical Pharmacology·P Köpf-Maier
Jan 1, 1996·Investigational New Drugs·T SchillingA R Hanauske
Oct 6, 2000·Journal of Medicinal Chemistry·F CarusoC Pettinari
Jun 7, 2002·Critical Reviews in Oncology/hematology·Enrique Meléndez
Aug 22, 2002·Current Cancer Drug Targets·Angela CasiniLaudiu T Supuran
Apr 8, 2003·Current Medicinal Chemistry·Andrea ScozzafavaClaudiu T Supuran
Feb 3, 2004·Mini Reviews in Medicinal Chemistry·Francesco Caruso, Miriam Rossi
Jul 15, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R HamidP Bullock
May 16, 2006·Apoptosis : an International Journal on Programmed Cell Death·K O'ConnorR W G Watson
Aug 8, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·P Manohari Abeysinghe, Margaret M Harding
Aug 8, 2007·Bioorganic & Medicinal Chemistry Letters·Adam J SalmonSally-Ann Poulsen
Aug 19, 2007·The American Journal of the Medical Sciences·Xin YaoKenneth Nugent
Dec 25, 2007·Acta Crystallographica. Section A, Foundations of Crystallography·George M Sheldrick
Jan 30, 2008·Journal of the American Chemical Society·Arthur D TinocoAnn M Valentine
Feb 19, 2008·Cancer Treatment Reviews·Andreas A ArgyriouHaralabos P Kalofonos
Jan 14, 2009·Molecular Cancer Therapeutics·Sarah R McWhinneyHoward L McLeod
Jan 28, 2010·Chemistry : a European Journal·Timo A ImmelThomas Huhn
Nov 15, 2011·Chemical Reviews·Katherine M Buettner, Ann M Valentine
Mar 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Arthur D TinocoAnn M Valentine
Nov 10, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Stuart L HancockMatthew D Jones
May 2, 2014·ChemMedChem·Rianne M LordPatrick C McGowan

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Citations

Nov 20, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Georges KhalilPierre Mobian
May 30, 2021·Journal of Inorganic Biochemistry·Gilad NahariEdit Y Tshuva
Aug 8, 2021·Journal of Inorganic Biochemistry·Rosario SerranoMaria Jose Ruiz
Aug 19, 2020·Inorganic Chemistry·Matthieu Scarpi-LuttenauerPierre Mobian

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