Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives

European Journal of Medicinal Chemistry
Daniela SecciAlessandra Zicari

Abstract

Novel (4-(4-iodophenyl)-thiazol-2-yl)hydrazine derivatives were assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-seven clinical isolates. The presence of aliphatic chains or specific heteroaromatic rings on hydrazone moiety at position C2 and a 4-iodophenyl at C4 of the thiazole ring gave a promising inhibitory activity especially against Candida albicans and Candida krusei. The most active compounds have been also evaluated for their cytotoxicity and in association with clotrimazole for anti-Candida activity.

Citations

May 25, 2013·European Journal of Medicinal Chemistry·Simone CarradoriBruna Bizzarri
Sep 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristina NastasăOvidiu Oniga
Mar 18, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Maria Concetta GidaroSimone Carradori
May 15, 2015·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Mohammed F El-BehairyMohamed N Aboul-Enein
May 11, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Simone CarradoriLetizia Angiolella
May 20, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Krzysztof Z ŁączkowskiAnna Malm
Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anca-Maria BorceaOvidiu Oniga
Aug 5, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Cristina CampestreSimone Carradori
Jul 3, 2021·Materials·Przemysław KrawczykKrzysztof Z Łączkowski

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