Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates

Bioorganic & Medicinal Chemistry Letters
Ahmed KamalSurekha Zingde

Abstract

A series of novel anthranilamide linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates were prepared and evaluated for their anticancer activity. The effects of three promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These promising compounds showed the characteristic features of apoptosis like enhancement in the levels of p53 and activation of caspase-3.

Citations

Dec 21, 2010·Chemical Reviews·Dyeison Antonow, D E Thurston
Jul 5, 2016·Acta Crystallographica. Section E, Crystallographic Communications·Inese MierinaMara Jure

Related Concepts

Anthranilamide
Pyrrolobenzodiazepine
Antineoplastic Agents
Benzodiazepines
Cell Cycle
Flow Cytometry
Pyrroles
Protein p53
Apoptosis, Intrinsic Pathway
Cell Line, Tumor

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis