Synthesis, antifungal and antibacterial activity of novel 1,2,4-triazole derivatives

Journal of Advanced Pharmaceutical Technology & Research
Deepa Gupta, D K Jain

Abstract

A large number of 1,2,4-triazole-containing ring system have been incorporated into a wide variety of therapeutically interesting drug candidates including anti-inflammatory, central nervous system stimulants, antianxiety, and antimicrobial agents. To overcome the rapid development of drug resistance, new agents should preferably have chemical characteristics that clearly differ from those of existing agents. Thus led to the design and synthesize the new antimicrobial agents. A novel series of Schiff bases based on of 4-(benzylideneamino)-5-phenyl-4H-1,2,4-triazole-3-thiol scaffold was prepared by heating thiocarbohydrazide and substituted benzoic acid and subsequently, treating with substituted benzaldehydes. Seventeen derivatives were synthesized and were biologically screened for antifungal and antibacterial activity. The newly synthesized derivatives of triazole showed antifungal activity against fungal species, Microsporum gypseum; and antibacterial activity against bacterial species, Staphylococcus aureus. It was observed that none of the compounds tested showed positive results for fungi Candida albicans fungi Aspergillus niger, nor against bacterial strain Escherichia coli. Strong antifungal effects were obtained for th...Continue Reading

Citations

Mar 14, 2019·Mini Reviews in Medicinal Chemistry·Ankit Jain, Poonam Piplani
May 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Birutė Sapijanskaitė-BanevičEglė Mickevičiūtė
Jul 6, 2020·Current Topics in Medicinal Chemistry·Christophe Tratrat
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicolae BaranovCorina Cheptea
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marina ZveaghintsevaFliur Z Macaev

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BETA
NMR

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