Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines

European Journal of Medicinal Chemistry
R RamajayamConstantin Radu

Abstract

The synthesis, antileukemic and antiplatelet activity evaluation of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines are described. In general, it was found that compound 17o showed moderate antileukemic activity against MOLT3 human leukemic cancer cell lines. An arachidonic acid induced platelet aggregation effect on washed rat platelets was studied. Compound 17i was found to be the most potent. The antiplatelet properties may be mediated by interference with the arachidonic acid pathway.

Citations

Dec 10, 2015·Chemical Biology & Drug Design·Chunqi HuWenting Du
Feb 6, 2008·Steroids·Malika Ibrahim-Ouali, Luc Rocheblave
Mar 24, 2016·Antimicrobial Agents and Chemotherapy·Vanessa KaplumCelso Vataru Nakamura
Nov 30, 2019·Future Medicinal Chemistry·Shalki Choudhary, Om Silakari
Jun 27, 2014·Organic & Biomolecular Chemistry·Daniele RagnoAnna Zaghi

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