Synthesis, antimicrobial activity of Schiff base compounds of cinnamaldehyde and amino acids.

Bioorganic & Medicinal Chemistry Letters
Hui WangMingyue Jiang

Abstract

The purpose of this study was to synthesize hydrophilic cinnamaldehyde Schiff base compounds and investigate those bioactivity. A total of 24 Schiff base compounds were synthesized using a simple approach with 3 cinnamaldehyde derivates and 8 amino acids as raw materials. The structures of synthesized compounds were confirmed using FTIR, (1)HNMR, HRMS purity and melting point. The antimicrobial activities of new compounds were evaluated with fluconazole and ciprofloxacin as the control against Aspergillus niger, Penicillium citrinum, Escherichia coli and Staphylococcus aureus. Findings show that major compounds exhibited significant bioactivity. Results from the structure-activity relationship suggest that both -p-Cl on benzene ring of cinnamaldehyde and the number of -COOK of amino acid salts significantly contributed to antimicrobial activity.

References

Jul 13, 2004·International Journal of Food Microbiology·Sara Burt
Apr 9, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Sheikh ShreazLuqman A Khan

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Citations

Nov 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dongmei YangShujun Li
Aug 11, 2020·Letters in Applied Microbiology·T F F Magalhães de Fátima
Nov 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui WangChunde Jin
Nov 11, 2019·Fitoterapia·Amanda A Doyle, John C Stephens

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