Synthesis, characterization, and antibacterial activity of three palladium(II) complexes of tetracyclines

Journal of Inorganic Biochemistry
Wendell GuerraElene C Pereira-Maia

Abstract

Pd(II) complexes with three antibiotics of the tetracycline family (tetracycline, doxycycline and chlortetracycline) were synthesized and characterized by elemental, thermogravimetric, and conductivity analyses, and infrared spectroscopy. The interactions between Pd(II) ions and tetracycline were investigated in aqueous solution by (1)H NMR. All the tetracyclines studied form 1:1 complexes with Pd(II) via the oxygen of the hydroxyl group at ring A and that of the amide group. The effect of the three complexes on the growth of bacterial strains sensitive and resistant to tetracycline was studied. The Pd(II) complex of tetracycline is practically as efficient as tetracycline in inhibiting the growth of two Escherichia coli (E. coli) sensitive bacterial strains and 16 times more potent against E. coli HB101/pBR322, a bacterial strain resistant to tetracycline. Pd(II) coordination to doxycycline also increased its activity in the resistant strain by a factor of 2.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F BolivarH W Boyer
Jan 1, 1978·Advances in Pharmacology and Chemotherapy·J R Brown, D S Ireland
May 10, 1975·Journal of the American Chemical Society·D E Williamson, G W Everett
Oct 25, 1975·Journal of the American Chemical Society·J Gulbis, G W Everett
Oct 1, 1992·Clinical Microbiology Reviews·B S SpeerA A Salyers
Apr 1, 1992·Antimicrobial Agents and Chemotherapy·S B Levy
Mar 1, 1992·The Journal of Antimicrobial Chemotherapy·I ChopraM Hinton
Jan 1, 1990·Molecular Microbiology·A A SalyersN B Shoemaker
Jul 1, 1974·Journal of Pharmaceutical Sciences·G L AslesonC W Frank
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L McMurryS B Levy
Dec 22, 1999·Journal of Inorganic Biochemistry·F C de PaulaE C Pereira-Maia
May 31, 2001·Microbiology and Molecular Biology Reviews : MMBR·I Chopra, M Roberts
Apr 19, 2005·Journal of Inorganic Biochemistry·Edmar Chartone-SouzaElene C Pereira-Maia

❮ Previous
Next ❯

Citations

Dec 3, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Aline Luciano FilgueirasAntonio C Sant'Ana
Dec 23, 2016·Environmental Pollution·Rama PulicharlaRao Y Surampalli
Oct 31, 2008·Chemistry & Biodiversity·Flávia C S de PaulaElene C Pereira-Maia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.