Synthesis, characterization and antibacterial activity of some triazole Mannich bases carrying diphenylsulfone moieties

European Journal of Medicinal Chemistry
Gabriela Laura AlmajanGabriel Saramet

Abstract

A series of Mannich bases of 4-substituted 5-[4-(4-X-phenylsulfonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-thiones, X=H, Cl, Br, 3 and 5 were synthesized and characterized on the basis of IR, NMR and elemental analyses. The potential antibacterial effects of the synthesized compounds were investigated using the Acinetobacter baumanii ATCC 19606; Citrobacter freundii ATCC 8090; Pseudomonas aeruginosa ATCC 9027; Enterococcus faecalis ATCC 19433; Staphylococcus aureus ATCC 12600; Staphylococcus epidermidis ATCC 14990; Bacillus subtilis ATCC 6633 strains. Some of them exhibited promising activities against A. baumanii and B. subtilis.

Citations

Apr 2, 2013·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Tomasz PlechAnna Malm
Dec 3, 2014·European Journal of Medicinal Chemistry·Gheorghe Roman
Aug 5, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomasz PlechGabriel Nowak
Apr 11, 2014·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Serap BasogluNeslihan Demirbas
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