Synthesis, characterization, and antimicrobial activity of kojic acid grafted chitosan oligosaccharide

Journal of Agricultural and Food Chemistry
Xiaoli LiuPeipei Yu

Abstract

A novel water-soluble chitosan oligosaccharide (COS) derivative, chitosan oligosaccharide/kojic acid grafts assigned as COS/KA, was prepared by using the selective partial alkylation of N-benzylidene COS and chlorokojic acid in the presence of dimethyl sulfoxide (DMSO) and pyridine (Py). The derivative was characterized by UV-vis spectroscopy, FTIR, (1)H NMR, TGA, SEM, and XRD techniques, which showed that the alkylation reaction took place at the C-6 and C-3 positions of COS. The results showed that the degree of substitution (DS) for COS/KA was from 0.38 to 1.21, and the product exhibited an excellent solubility in organic solvents and distilled water. The antibacterial results indicated that the antibacterial activity of COS/KA was strengthened relative to COS with the increase of DS for Staphylococcus aureus , Escherichia coli , Aspergillus niger and Saccharomyces cerevisiae . These findings provide important supports for developing new antibacterial agents and expand the scope of application of COS in the food industry.

References

Mar 22, 2001·Regulatory Toxicology and Pharmacology : RTP·G A BurdockI G Carabin
Apr 4, 2002·International Journal of Food Microbiology·Hong Kyoon NoSamuel P Meyers
Aug 22, 2002·Journal of Agricultural and Food Chemistry·You-Jin JeonFereidoon Shahidi
Feb 1, 2003·International Journal of Biological Macromolecules·Caiqin QinXiaohai Gao
Aug 9, 2003·Journal of Pharmaceutical and Biomedical Analysis·M LavertuAjay Gupta
Mar 3, 2006·Archiv der Pharmazie·Yong Sup LeeHyoung Ja Kim
Aug 3, 2006·Journal of Agricultural and Food Chemistry·Jong-Whan RhimPerry K W Ng
Jun 1, 2007·The Journal of Toxicological Sciences·Yoshitaka HigaMichihito Takahashi
Feb 29, 2008·Organic Letters·Xin Xiong, Michael C Pirrung
Jul 2, 2010·European Journal of Medicinal Chemistry·Mutlu Dilsiz Aytemir, Berrin Ozçelik
Feb 1, 2011·International Journal of Biological Macromolecules·Jiangtao Wang, Hedong Wang

❮ Previous
Next ❯

Citations

Nov 15, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jong H Kim, Kathleen L Chan
Jun 4, 2015·Journal of Agricultural and Food Chemistry·Juliana dos Santos GabrielVera Aparecida de Oliveira Tiera
Nov 26, 2015·Food Chemistry·Ruixiu JiaJianying Huang
May 18, 2016·International Journal of Biological Macromolecules·Hongli LiuWenshui Xia
Oct 30, 2016·Pharmacology & Therapeutics·Chatchai Muanprasat, Varanuj Chatsudthipong
Aug 17, 2018·Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional·Yu WuJuan Zhang
Jul 9, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Parinaz SabourianAshok Kakkar
Nov 16, 2020·International Journal of Biological Macromolecules·Shuifang MaoWenshui Xia
Dec 22, 2020·Frontiers in Microbiology·Aline Midori KanashiroTaícia Pacheco Fill
May 24, 2021·European Journal of Medicinal Chemistry·Min HeGuangcheng Wang
Jun 12, 2021·Biopolymers·Camille ChapelleMyriam Desroches Le Foll
Aug 19, 2020·ACS Applied Materials & Interfaces·Lin MeiJunxia Zhang
Nov 6, 2020·The Journal of Organic Chemistry·Xiangyu SunYangjie Wu
Jul 10, 2019·The Journal of Organic Chemistry·Mingshan WangLing Pan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.