Synthesis, characterization and antitumor properties of selenium nanoparticles coupling with ferulic acid

Materials Science & Engineering. C, Materials for Biological Applications
Dongxiao CuiQingshan Li

Abstract

Selenium nanoparticles (Se NPs) attract a lot of attention as potential cancer therapeutic agents. However, the antitumor activities of pure Se NPs are poor, and some modifiers are needed to enhance the activities. In the present study, we prepared Ferulic Acid (FA)-modified selenium nanoparticles in a facile synthetic approach. The obtained FA-Se NPs were characterized using transmission electron microscope (TEM), dynamic light scattering (DLS), ultraviolet-visible spectrophotometer (UV-VIS), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Energy dispersive X-ray (EDX) spectroscopy. In vitro antitumor effects of FA, Se NPs and FA-Se NPs in HepG-2 cells were examined by methyl thiazolyl tetrazolium (MTT) assay. It showed that FA-Se NPs effectively inhibited the growth of HepG-2 cells with IC50 value of 11.57 ± 3.6 μg/ml, while the value of Se NPs was >100 μg/ml. In addition, FA behaves no obvious antitumor effects at high concentrations up to 100 μg/ml. In order to investigate the antitumor mechanism of FA-Se NPs, fluorescence morphological examination and Annexin V-FITC/PI staining analysis were performed to observe the apoptosis of HepG-2 cells induced by FA-Se NPs. Meanwhile, mitochondrial membran...Continue Reading

Citations

Dec 27, 2018·International Journal of Molecular Sciences·Heng Wee TanYan-Ming Xu
Nov 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristina MellinasMaría Del Carmen Garrigós
Aug 29, 2020·Critical Reviews in Biotechnology·Jesus J OjedaPhilip H E Gardiner
Oct 12, 2018·Nutrients·Diana Constantinescu-AruxandeiFlorin Oancea
Oct 3, 2020·International Journal of Molecular Sciences·Nikita Simone PillayMoganavelli Singh
Jun 15, 2021·Advanced Healthcare Materials·Cláudio FerroHélder A Santos
Jul 30, 2021·Advanced Science·Yuezhou ZhangWei Huang
Aug 17, 2021·Frontiers in Pharmacology·Wensen LinJiang Pi

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