Synthesis, characterization, and application of polysodium N-alkylenyl α-d-glucopyranoside surfactants for micellar electrokinetic chromatography-tandem mass spectrometry

Electrophoresis
Yijin LiuS A Shamsi

Abstract

Sugar-based ionic surfactants forming micelles are known to suppress ESI of various compounds due to decrease in surface tension upon micelle formation . For the first time, poly (sodium N-undecylenyl-α-d-glucopyranoside 4,6-hydrogen phosphate, (poly-α-d-SUGP) based surfactants with different chain lengths and head groups have been successfully synthesized, characterized, and applied as compatible chiral selector for MEKC-ESI-MS/MS. First, the effect of polymerization concentration of the monomer, α-d-SUGP, was evaluated by enantioseparation of one anionic compound (1,1'-binaphthyl-2,2'diyl-hydrogen phosphate) and one zwitterionic compound (dansylated phenylalanine) in MEKC-UV to find the optimum molar surfactant concentration for polymerization. Next, MEKC-UV and MEKC-MS were compared for the enantioseparation of 1,1'-binaphthyl-2,2'diyl-hydrogen phosphate. The influence of polymeric glucopyranoside based surfactant head groups and carbon chain lengths on chiral Rs was evaluated for two classes of cationic drugs (ephedrine alkaloids and β-blockers). Finally, enantioselective MEKC-MS of ephedrine alkaloids and β-blockers were profiled at their optimum pH 5.0 and 7.0, respectively, using 20 mM NH4 OAc, 25 mM poly-α-d-SUGP at 30 ...Continue Reading

References

Nov 18, 2000·Analytical Biochemistry·Y IshihamaN Asakawa
Apr 11, 2009·Electrophoresis·Alessandro GiuffridaAlejandro Cifuentes
Nov 3, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·J YuK R Kim
Nov 23, 2013·Electrophoresis·Alain WuethrichJoselito P Quirino

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Citations

Dec 7, 2016·Electrophoresis·Ioannis J StavrouConstantina P Kapnissi-Christodoulou
Aug 17, 2020·Journal of Chromatography. a·Sandra Salido-FortunaMaría Luisa Marina
Jan 4, 2018·Analytical Chemistry·Robert L C VoetenGovert W Somsen

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