Synthesis, characterization, and biocompatible properties of alanine-grafted chitosan copolymers

Journal of Biomaterials Applications
Gyu Han ParkMyoung-Seon Gong

Abstract

In order to overcome major problems regarding the lack of affinity to solvents and limited reactivity of the free amines of chitosan, introduction of appropriate spacer arms having terminal amine function is considered of interest. L-Alanine-N-carboxyanhydride was grafted onto chitosan via anionic ring-opening polymerization. The chemical and structural characterizations of L-alanine-grafted chitosan (Ala-g-Cts) were confirmed through Fourier transform infrared spectroscopy and proton nuclear magnetic resonance spectroscopy ((1)H NMR). In addition, the viscoelastic properties of Ala-g-Cts were examined by means of a rotational viscometer, and thermal analysis was carried out with a thermogravimetric analyzer and differential scanning calorimetry. Morphological changes in the chitosan L-alanine moiety were determined by x-ray diffraction. To determine the feasibility of using these films as biomedical materials, we investigated the effects of their L-alanine content on physical and mechanical properties. The biodegradation results of crosslinked Ala-g-Cts films were evaluated in phosphate-buffered solution containing lysozyme at 37℃. Proliferation of MC3T3-E1 cells on crosslinked Ala-g-Cts films was also investigated with use of...Continue Reading

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Citations

Sep 19, 2018·Journal of Biomaterials Applications·Moataz DowaidarXiaodong Zou
Feb 2, 2017·Beilstein Journal of Nanotechnology·Huijuan ZhangLee Jia
Feb 18, 2021·Carbohydrate Polymers·Sara TorkamanSeyed Heydar Mahmoudi Najafi

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Methods Mentioned

BETA
acetylation
nuclear magnetic resonance
differential scanning calorimetry
x-ray diffraction
x-ray powder diffraction
chemical

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