PMID: 11931961Apr 5, 2002Paper

Synthesis, characterization and biological activity of two new polymeric copper(II) complexes with alpha-ketoglutaric acid thiosemicarbazone

Journal of Inorganic Biochemistry
M Belicchi FerrariS Pinelli

Abstract

In this paper we describe the synthesis of new copper complexes with alpha-ketoglutaric acid thiosemicarbazone. The crystal structures of the two compounds: [Cu(H(2)ct)Cl](n) [(Cu(H(2)ct)Cl)(2)] (1) and [Cu(Hct)](n).3nH(2)O (2) (H(3)ct=alpha-ketoglutaric acid thiosemicarbazone) have been determined by X-ray and spectroscopic methods. In 1 two independent copper atoms are present. Cu(1), in a nitrogen- and oxygen-bridged polymer, is a six-coordinated (4+2), Cu(2), five coordinated (4+1), is a chlorine-bridged dimer. In 2 the copper atom presents a penta-coordination, polymeric chains form layers and the -CH(2)CH(2)COO(-) groups bridge copper atoms. In 1 a monodentate and in 2 a syn-anti bidentate bridging carboxylate are present. The biological properties of 1 and 2 and also of the free ligand (H(3)ct) were tested in vitro and compared on Friend erythroleukemia cells (FLC) and on human leukemia cell lines K562 and U937. On the FLC cells the free ligand does not inhibit cell growth, but increases the DNA synthesis; complex 1 inhibits cell proliferation and increases the DNA synthesis; complex 2 inhibits cell growth, but induces a decrement of DNA synthesis and increases the reverse transcriptase activity. Regarding the human cell...Continue Reading

References

Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S H OrkinP Leder
Jan 1, 1994·Leukemia & Lymphoma·X LiZ Darzynkiewicz
Sep 30, 1998·Cell·D R Green

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Citations

Jan 7, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Ola A El-GammalMohammed M El-Gamil
Feb 26, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·May Lee LowClotilde Policar
Nov 12, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Rubén Gil-GarcíaJavier García-Tojal
Jun 27, 2018·Drug and Chemical Toxicology·Ahmed Medhat HegazyRania M Eid
Jul 31, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry· SaswatiRupam Dinda
Jan 29, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Piersandro PallaviciniAngelo Taglietti
Sep 2, 2018·Journal of Fluorescence·C Shobha DeviPenumaka Nagababu
Jul 5, 2019·Acta Crystallographica. Section C, Structural Chemistry·Xia WangYawen Zhang
Apr 6, 2021·Bioinorganic Chemistry and Applications·Khlood S Abou MelhaNashwa El-Metwaly
May 10, 2005·Journal of Inorganic Biochemistry·Giselle CerchiaroAna Maria Da Costa Ferreira
Aug 12, 2008·Journal of Inorganic Biochemistry·Patricia Gómez-SaizJavier García-Tojal

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