Synthesis, characterization, and biological evaluation of Schiff base-platinum(II) complexes

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
C ShijuS Kumaresan

Abstract

The platinum complexes of Schiff base ligands derived from 4-aminoantipyrine and a few substituted aldehydes were synthesized and characterized by elemental analysis, mass, (1)H NMR, IR, electronic spectra, molar conductance, and powder XRD. The structure of one of the ligands L5 was confirmed by a single crystal XRD analysis. The Schiff base ligand crystallized in the triclinic, space group P-1 with a=7.032(2)Ǻ, b=9.479(3)Ǻ, c=12.425(4)Ǻ, α=101.636(3)°, β=99.633(3)°, γ=94.040(3)°, V=795.0(4)Ǻ(3), Z=2, F(000)=352, Dc=1.405 mg/m(3), μ=0.099 mm(-1), R=0.0378, and wR=0.0967. The spectral results show that the Schiff base ligand acts as a bidentate donor coordinating through the azomethine nitrogen and the carbonyl oxygen atoms. The geometrical structures of these complexes are found to be square planar. Antimicrobial studies indicate that these complexes exhibit better activity than the ligand. The anticancer activities of the complexes have also been studied towards human cervical cancer cell line (HeLa), Colon Cancer Cells (HCT116) and Epidermoid Carcinoma Cells (A431) and it was found that the [Pt(L3)Cl2] complex is more active.

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Citations

May 20, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·A A M BelalMoamen S Refat
Dec 6, 2016·Journal of Biomolecular Structure & Dynamics·Miral V LunagariyaMohan N Patel
Aug 9, 2019·Journal of Biochemical and Molecular Toxicology·Mediha SüleymanoğluBahri Ülküseven
Sep 24, 2015·Acta Crystallographica. Section E, Crystallographic Communications·Kamel OuariLydia Karmazin
Dec 22, 2020·European Journal of Medicinal Chemistry·Ying SunWukun Liu

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