Synthesis, characterization and biological evaluation of (99m)Tc/Re-tricarbonyl quinolone complexes

Journal of Inorganic Biochemistry
Theocharis E KydonakiGeorge Psomas

Abstract

New rhenium(I) tricarbonyl complexes with the quinolone antimicrobial agents oxolinic acid (Hoxo) and enrofloxacin (Herx) and containing methanol, triphenylphosphine (PPh3) or imidazole (im) as unidentate co-ligands, were synthesized and characterized. The crystal structure of complex [Re(CO)3(oxo)(PPh3)]∙0.5MeOH was determined by X-ray crystallography. The deprotonated quinolone ligands are bound bidentately to rhenium(I) ion through the pyridone oxygen and a carboxylate oxygen. The binding of the rhenium complexes to calf-thymus DNA (CT DNA) was monitored by UV spectroscopy, viscosity measurements and competitive studies with ethidium bromide; intercalation was suggested as the most possible mode and the DNA-binding constants of the complexes were calculated. The rhenium complex [Re(CO)3(erx)(im)] was assayed for its topoisomerase IIα inhibition activity and was found to be active at 100μM concentration. The interaction of the rhenium complexes with human or bovine serum albumin was investigated by fluorescence emission spectroscopy (through the tryptophan quenching) and the corresponding binding constants were determined. The tracer complex [(99m)Tc(CO)3(erx)(im)] was synthesized and identified by comparative HPLC analysis w...Continue Reading

References

Dec 5, 2000·The Journal of Antimicrobial Chemotherapy·M D Cubbon, R G Masterton
Nov 7, 2006·Cellular and Molecular Life Sciences : CMLS·O H LaitinenM S Kulomaa
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Aug 20, 2014·ACS Chemical Biology·Anna Leonidova, Gilles Gasser

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Citations

Dec 3, 2016·Journal of Inorganic Biochemistry·Elisa PalmaAntónio Paulo
Jun 16, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Chilaluck C KonkankitJustin J Wilson
Sep 8, 2018·Acta Crystallographica. Section C, Structural Chemistry·Wun Fui Mark-LeeMohammad B Kassim
May 17, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Marietjie Schutte-SmithHendrik G Visser

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