Synthesis, characterization, and biological verification of anti-HER2 indocyanine green-doxorubicin-loaded polyethyleneimine-coated perfluorocarbon double nanoemulsions for targeted photochemotherapy of breast cancer cells

Journal of Nanobiotechnology
Yu-Hsiang Lee, Yun-Ting Ma

Abstract

Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide. Among various types of breast cancer, the human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer is known to be more aggressive and often resistant to medicinal treatment, leading to an insufficient prognosis and poor susceptibility to chemotherapy and/or hormonal therapy in the current clinic. These circumstances implicate that developing an improved therapeutic strategy rather than persistently changing the anticancer drugs for trying is truly needed to successfully cure this type of breast cancer. In this study, we aimed to fabricate anti-HER2 indocyanine green (ICG)-doxorubicin (DOX)-loaded polyethyleneimine-coated perfluorocarbon double nanoemulsions (HIDPPDNEs) to explore the co-administration of phototherapy and chemotherapy for HER2-overexpressing breast cancer in vitro. The HIDPPDNE was first characterized as a sphere-like nanoparticle with surface charge of -57.1 ± 5.6 mV and size of 340.6 ± 4.5 nm, whereas the DOX release rates for the nanodroplets within 48 h in 4 and 37 °C were obtained by 8.13 ± 2.46% and 19.88 ± 2.75%, respectively. We then examined the target-ability of the n...Continue Reading

References

Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·O BoussifJ P Behr
Sep 3, 2002·Advanced Drug Delivery Reviews·Alexander V KabanovValery Yu Alakhov
May 2, 2003·Nature Reviews. Cancer·Dennis E J G J DolmansRakesh K Jain
Sep 23, 2003·Journal of Pharmaceutical Sciences·Vishal SaxenaJun Shao
Mar 27, 2004·Journal of Photochemistry and Photobiology. B, Biology·Vishal SaxenaJun Shao
Feb 3, 2005·Breast Disease·A Choudhury, R Kiessling
Jul 27, 2006·JAMA : the Journal of the American Medical Association·Donald S CoffeyTheodore L DeWeese
Dec 23, 2006·Biochemical and Biophysical Research Communications·Oshrat Harush-FrenkelYoram Altschuler
Aug 4, 2007·Lasers in Medical Science·Xiaohua HuangMostafa A El-Sayed
Feb 22, 2008·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·K K Jain
May 12, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Chuda ChittasuphoCory J Berkland
Dec 18, 2009·Cardiology·Kanu ChatterjeeJoel S Karliner
Jan 5, 2010·Free Radical Biology & Medicine·Magdalena L Circu, Tak Yee Aw
Apr 16, 2011·Journal of Surgical Oncology·Boudewijn E SchaafsmaAlexander L Vahrmeijer
Feb 2, 2012·International Journal of Breast Cancer·Gabriel L Fiszman, María A Jasnis
May 1, 2012·Pharmacological Reviews·José M MorachisAdah Almutairi
Jun 2, 2012·Colloids and Surfaces. B, Biointerfaces·Christopher A FrakerCherie L Stabler
Jan 3, 2013·The Journal of Pharmacy and Pharmacology·Oktay TacarCrispin R Dass
Feb 7, 2013·Journal of Cancer·Gabriel TinocoAlberto J Montero
Feb 25, 2014·Nature Reviews. Cancer·Katrina F Chu, Damian E Dupuy
Sep 27, 2014·Chemical Reviews·Liang ChengZhuang Liu
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jun 10, 2015·Chemical Society Reviews·Thomas L MooreAlke Petri-Fink
Sep 9, 2015·Neuropsychiatric Disease and Treatment·Theodore A Henderson, Larry D Morries
Oct 8, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Min-Cheol KimDo Kyung Kim
Oct 21, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vaibhav MundraRam I Mahato
Oct 23, 2015·Journal of Ophthalmology·Rodolfo MastropasquaLeonardo Mastropasqua

❮ Previous
Next ❯

Citations

Apr 7, 2019·Journal of Nanobiotechnology·Jihwan SonHeebeom Koo
Sep 6, 2019·Pharmaceutical Nanotechnology·Ranjit K HarwanshMd Akhlaquer Rahman
Oct 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Salvador GomezZhiwei Hu
Jun 14, 2021·Advances in Colloid and Interface Science·Marie Pierre Krafft, Jean G Riess
Aug 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhaoguo HanZhanhong Wu
Oct 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Linyun HeChihua Fang

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance
dynamic light scattering
fluorescence microscopy

Software Mentioned

MedCalc

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.