Synthesis, Characterization, and Biological Evaluation of Unimetallic and Heterobimetallic Complexes of Bivalent Copper

Bioinorganic Chemistry and Applications
Anshul Singh, Ashu Chaudhary

Abstract

We present an inclusive characterization of the unimetallic and heterobimetallic complexes of copper synthesized using CuCl2 and diamine (4-fluoro 1,2-phenylenediamine) resulting in monometallic complex which further undergoes treatment with organometallic dichlorides of group 4 and 14 in 1 : 2 molar ratio resulting in heterobimetallic complexes. These complexes thoroughly characterized using various physical, analytical, and spectroscopic techniques indicate square planar and distorted octahedral geometry for the synthesized unimetallic and heterobimetallic complexes, respectively. These complexes were evaluated for their antimicrobial efficacy against various bacterial and fungal strains while hepatoprotective activity was also examined in male albino rats.

References

Oct 10, 2013·Chemical Reviews·Carlo SantiniCristina Marzano
Dec 10, 2014·Journal of Photochemistry and Photobiology. B, Biology·Hina ZafarTahir Ali Khan
Oct 16, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Tao HuangRoger D Sommer
Jun 16, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Ying XiaoHui Li
Apr 4, 2017·European Journal of Medicinal Chemistry·Melanie JoppSiegfried Schindler
Nov 10, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Hajar MolaeeMozhgan Samandar Sangari

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Methods Mentioned

BETA
Assay
ESR
X-ray

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