PMID: 2092075Oct 1, 1990Paper

Synthesis, characterization, and DNA binding studies of some mixed-ligand platinum(II) complexes of 1,10-phenanthroline and amino acids

Journal of Inorganic Biochemistry
R Mital, T S Srivastava

Abstract

A series of complexes of the type [Pt(phen)(AA)]+ (where AA is the anion of glycine, L-alanine, L-leucine, L-phenylalanine, L-tyrosine, or L-tryptophan) has been synthesized. These complexes have been characterized by electronic absorption, infrared, and 1H NMR spectroscopy. The interaction of these complexes with calf thymus DNA has been studied using fluorescence spectroscopy. They inhibit the intercalation of ethidium bromide in DNA by intercalative binding at low concentrations and show nonintercalative binding at higher concentrations.

References

Jun 1, 1986·Journal of Inorganic Biochemistry·R MitalR K Bhattacharya
Jun 1, 1972·Journal of Comparative and Physiological Psychology·G L GregorH B Parker

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Citations

Oct 10, 1998·International Journal of Cancer. Journal International Du Cancer·J J MarinM A Serrano
Dec 30, 2009·Journal of Enzyme Inhibition and Medicinal Chemistry·Enjun GaoNi Wang
Aug 10, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Enjun GaoXianan Gao

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