Synthesis, characterization and electronic spectra of cefadroxil complexes of d-block elements

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
M A Zayed, S M Abdallah

Abstract

Cefadroxil (CD) is an essential pharmaceutical drug used in curing many diseases. Due to its popular use in many pharmaceutical forms, attention is paid in this research to the synthesis and stereochemistry of new iron, cobalt, nickel, copper, and zinc complexes of this drug both in solution and the solid states. The spectra of these complexes in solution and the study of their stoichiometry refer to the formation of 1:1 and 1:2 ratios of metal (M) to ligand (L). The calculated stability constants (Kf) of these complexes (1.5x10(7) to 5x10(13)) and the change in free energy of formation (deltaGf=2.5-12.5 kcal mol(-1) degree(-1)) are indicative of their high stability. The stereo chemical structure of the solid complexes was studied on the basis of their analytical, spectroscopic, magnetic, and thermal data. Infrared spectra proved the presence of M-N and M-O bonds. Magnetic susceptibility and solid reflectance spectral measurements were used to infer the structure. The prepared complexes were found to have the general formulae [ML(OH)x(H2O)y](H2O)z-M: Fe(II), x=0, y=2, z=1; M: Fe(III) and Co(III), x=1, y=2, z=1; M: Co(II) and Zn(II), x=0, y=1, z=0; M: Ni(II) and Cu(II), x=1, y=0, z=1; L: CD. Octahedral and tetrahedral structure...Continue Reading

References

Feb 1, 1977·Antimicrobial Agents and Chemotherapy·R E Buck, K E Price

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Citations

Jun 10, 2009·The Journal of Pharmacy and Pharmacology·Sayed H AudaReinhard H H Neubert
Feb 21, 2009·Electrophoresis·Sayed H AudaReinhard H H Neubert
Jan 3, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·M A ZayedM A Fahmey
Dec 15, 2009·Pharmaceuticals·Sayed H AudaReinhard H H Neubert

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