Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3',4':4,5]thieno[2,3-d]pyrimidine derivatives

Chemistry Central Journal
Mohamed A M Abdel Reheim, Safaa M Baker

Abstract

Some novel substituted pyrazolone, pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidinone, thieno[3,2-c]pyrazole and pyrazolo[3',4':4,5]thieno[2,3-d]pyrimidine derivatives have been reported to possess various pharmacological activities like antimicrobial, antitumor and anti-inflammatory. A novel series of azoles and azines were designed and prepared via reaction of 1,3-diphenyl-1H-pyrazol-5(4H)-one with some electrophilic and nucleophilic reagents. The structures of target compounds were confirmed by elemental analyses and spectral data. The antimicrobial activity of the target synthesized compounds were tested against various microorganisms such as Escherichia coli; Bacillus megaterium; Bacillus subtilis (Bacterial species), Fusarium proliferatum; Trichoderma harzianum; Aspergillus niger (fungal species) by the disc diffusion method. In general, the novel synthesized compounds showed a good antimicrobial activity against the previously mentioned microorganisms.

References

Mar 31, 2004·Bioorganic & Medicinal Chemistry·Adnan A Bekhit, Tarek Abdel-Aziem
Apr 21, 2005·Journal of Computational Chemistry·Art E ChoRichard Friesner
Jun 26, 2007·Bioorganic & Medicinal Chemistry Letters·María BarcelóMaría I Loza
Feb 8, 2008·European Journal of Medicinal Chemistry·Samir BondockAhmed A Fadda
Sep 12, 2008·Bioorganic & Medicinal Chemistry Letters·H N Hafez, A B A El-Gazzar
Mar 10, 2009·European Journal of Medicinal Chemistry·Mohamed Abdel-AzizAlaa A Hassan
Apr 29, 2009·European Journal of Medicinal Chemistry·Osama M AhmedSayed A Ahmed
Aug 4, 2009·European Journal of Medicinal Chemistry·P ManojkumarS Gopalakrishnan
Mar 17, 2010·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Eslam Reda El-SawyMohamed M Abdlla

❮ Previous
Next ❯

Citations

Jul 1, 2020·Antimicrobial Agents and Chemotherapy·Julianna Siciliano de AraújoMaria de Nazaré Correia Soeiro
Dec 20, 2018·Chemistry Central Journal·Rashmi Shah, Prabhakar Kumar Verma
Sep 27, 2019·European Journal of Medicinal Chemistry·Sanjay KumarInder Pal Singh
Nov 26, 2019·European Journal of Medicinal Chemistry·Zefeng ZhaoXiaohui Zheng
Apr 20, 2021·Journal of Agricultural and Food Chemistry·Jing-Wen PengYing-Qian Liu
Aug 5, 2020·Current Organic Synthesis·Mohamed Ahmed Elian Sophy, Mohamed Ahmed Mahmoud Abdel Reheim
Dec 4, 2020·Mini Reviews in Medicinal Chemistry·Neha V BhilareVilas J Pise
Jan 21, 2022·Future Medicinal Chemistry·Mohammad A Alam

❮ Previous
Next ❯

Methods Mentioned

BETA
acylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.