PMID: 11312677Apr 21, 2001Paper

Synthesis, characterization, and relaxivity of two linear Gd(DTPA)-polymer conjugates

Bioconjugate Chemistry
M G DuarteC F Geraldes

Abstract

Two linear polyamide conjugates of Gd(DTPA)2- were synthesized and characterized by high-resolution nuclear magnetic resonance (NMR) spectroscopy and size exclusion chromatography (SEC). DTPA was copolymerized with two different diamines, 1,6-hexanediamine and trans-1,4-cyclohexanediamine, yielding the polymers DTPA-HMD and DTPA-CHD, with low polydispersity. Their molecular flexibility in solution was studied using 13C spin-lattice relaxation time measurements, indicating that the cyclohexanediamine linking moiety of the DTPA-HMD polymer is more rigid than that of DTPA-CHD. The influence of the flexibility of the linking functionalities on the relaxivity of the Gd3+-DTPA-polymer conjugates was studied by water nuclear magnetic relaxation dispersion (NMRD). The relaxivity of the Gd(DTPA-CHD) polymer was only slightly higher than that of the Gd(DTPA-HMD) polymer, and only two times higher than the usual values for small Gd-DTPA-like chelates. The low relaxivities obtained for both polymers, much lower than expected from the polymer apparent molecular weights, result from their substantial residual flexibility, and also from a too long, nonoptimal, value of the inner-sphere water exchange rate. These polymeric compounds are also c...Continue Reading

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Citations

Jul 3, 2003·Bioorganic & Medicinal Chemistry·Jianghua FengMaili Liu
Oct 27, 2012·ACS Nano·Ching-Hui HuangAndrew Tsourkas
Aug 28, 2007·International Journal of Nanomedicine·Zheng-Rong LuYi Feng
Nov 26, 2010·Journal of Drug Targeting·Zhijin ChenZaijun Lu
Apr 1, 2015·Bioconjugate Chemistry·Victoria LeiroAna Paula Pêgo
Jan 29, 2011·International Journal of Pharmaceutics·Guo-Ping YanJun-Fang Guo
Jan 24, 2015·Bioconjugate Chemistry·Amit KumarXiankai Sun
Jan 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zheng-Rong LuHenry R Buswell
Dec 24, 2015·Advanced Healthcare Materials·Kerstin MalzahnKatharina Landfester
Feb 19, 2011·Israel Journal of Chemistry·Zheng-Rong Lu, Xueming Wu
Dec 10, 2003·Oncogene·Jonas A Nilsson, John L Cleveland
May 1, 2020·Biomaterials Science·Ratchapol JenjobDaniel Crespy
Jun 11, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Sara SilvérioCarlos F G C Geraldes
Oct 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yingying ChenAiguo Hu
Jun 24, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Zhiliang Cheng, Andrew Tsourkas
Dec 21, 2007·Bioconjugate Chemistry·Robie L LucasTheresa M Reineke

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