PMID: 11334187May 4, 2001Paper

Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid polymers. Part II: biodegradation

Journal of Biomaterials Science. Polymer Edition
X S Wu, N Wang

Abstract

A series of previously-synthesized lactic/glycolic acid polymers (PLGA) with various molar ratios of lactic to glycolic acid and various molecular weights were further studied with regard to their biodegradation behavior, and in particular, the factors affecting the biodegradation rate. The biodegradation of PLGA is affected by many factors including polymer composition, molecular weight, and nature of the incubating media. The biodegradation rate of PLGA containing higher content of lactic acid moiety is lower than those containing a lower content of lactic acid moiety. PLGAs with a higher molecular weight, degrade faster than those with a lower molecular weight, i.e. the molecular weight decreases more rapidly for higher molecular weight PLGAs than their lower molecular weight counterparts. Nature or properties of the hydrolysis/incubating media may have an effect on the biodegradation of PLGAs. A basic medium may slow down the biodegradation of PLGA in comparison with samples in an acidic medium. The rate of pH reduction for the incubating medium can be divided into three deferent phases, giving an inverted S-type pH profile for the non-buffered incubating media.

Citations

Mar 23, 2011·Annals of Biomedical Engineering·Ngan F Huang, Song Li
Jan 23, 2009·Journal of Materials Science. Materials in Medicine·G J S DawesJ Duszczyk
Aug 12, 2009·Journal of Materials Science. Materials in Medicine·G J S DawesJ Duszczyk
May 18, 2012·Journal of Materials Science. Materials in Medicine·Chong Wang, Min Wang
Mar 21, 2013·Acta Biomaterialia·Jan Willem M HoekstraJeroen J J P van den Beucken
Jan 29, 2013·Tissue Engineering. Part B, Reviews·Rosa P Félix LanaoSander C G Leeuwenburgh
Oct 25, 2008·Regenerative Medicine·Ngan F Huang, Song Li
Dec 15, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Robert FaloticoCampbell Rogers
Mar 5, 2014·International Journal of Molecular Sciences·Piergiorgio GentilePaul V Hatton
Jan 10, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Swati BiswasBalaram Ghosh
Jan 7, 2015·Journal of Microencapsulation·Kalpana DixitSarabjit Singh
Sep 17, 2010·Journal of Pharmaceutical Sciences·Aiying ZhaoV G J Rodgers
Dec 26, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Richard F AdamoMichael Chorny
Dec 25, 2010·International Journal of Pharmaceutics·Luciana Lisa LaoSubbu S Venkatraman
May 1, 2009·Colloids and Surfaces. B, Biointerfaces·J AraújoE B Souto
May 6, 2008·The Journal of Thoracic and Cardiovascular Surgery·Solomon M AzouzYolonda L Colson
Oct 19, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sridhar DuvvuriAshim K Mitra
Jan 31, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Theodore ParkerCampbell Rogers
Jul 11, 2012·Journal of Tissue Engineering and Regenerative Medicine·R P Félix LanaoJ A Jansen
Aug 27, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Surendranath R Veeram ReddyAlan W Nugent
Mar 28, 2013·Journal of Biomedical Materials Research. Part a·Amanda ClarkDavid A Puleo
May 13, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jacques Kameni TcheudjiNicolau Beckmann
Sep 5, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marianne ParentAriane Boudier
Apr 22, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yihan XuDonghun Koo
Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Noor AlamPrem N Gupta
Aug 21, 2016·International Journal of Pharmaceutics·Naihan ChenKristy M Ainslie
Aug 11, 2016·Journal of Biomedical Materials Research. Part a·Zhaowei ChuYubo Fan
Oct 28, 2016·Journal of Biomedical Materials Research. Part a·Remya Komeri, Jayabalan Muthu
Apr 29, 2016·Journal of Biomedical Materials Research. Part a·Zhaowei ChuYubo Fan
Feb 10, 2017·Journal of Dental Research·A S FawzyJ Neo
Feb 18, 2017·Pharmaceuticals·Olivia KoenigAndrea Nolte
Jan 1, 2010·Journal of Biomaterials Applications·Kamarza MuliaHubert Pellikaan
Jan 20, 2018·Advanced Materials·Jan-Kai ChangJohn A Rogers

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