Synthesis, computational, spectroscopic, thermal and antimicrobial activity studies on some metal-urate complexes

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Mamdouh S MasoudGehan S Elasala

Abstract

New sixteen uric acid metal complexes of different stoichiometry, stereo-chemistries and modes of interactions were synthesized using different metals Cr, Mn, Fe, Co, Ni, Cu, Cd, UO(2), Na and K. The synthesized complexes were characterized by elemental analysis, spectral (IR, UV-Vis and ESR) methods, thermal analysis (TG, DTA and DSC) and magnetic susceptibility studies. Molecular modeling calculations were used to characterize the ligation sites of the free ligand. Furthermore, quantum chemical parameters of uric acid such as the energies of highest occupied molecular orbital (E(HOMO)), energies of lowest unoccupied molecular orbital (E(LUMO)), the separation energy (ΔE=E(LUMO)-E(HOMO)), the absolute electronegativity, χ, the chemical potential, P(i), the absolute hardness, η and the softness (σ) were obtained for uric acid. Eight different microbial categories were used to study the antimicrobial activity of the free ligand and ten of its complexes. The results indicate that the ligand and its metal complexes possess antimicrobial properties. The stoichiometry of iron-uric acid complex was studied by using different spectrophotometric methods.

References

Nov 8, 1978·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·M Vogel
Dec 13, 2003·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mamdouh S MasoudAhmed S Goher
Sep 8, 2004·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mamdouh S MasoudEman F Mohamed
Oct 13, 2004·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mamdouh S MasoudMohamed Abdul Ghani
Feb 3, 2005·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·M S MasoudA F El-Husseiny
Oct 13, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mamdouh S MasoudAdel El-Marghany
Oct 13, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mamdouh S MasoudAmr Sweyllam
Mar 6, 2007·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Reeshemah N AllenJerzy Leszczynski
May 25, 2007·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mamdouh S MasoudGhada M El-Ashry
Jun 16, 2007·Organic & Biomolecular Chemistry·Ute MünchbergClaus Jacob

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Citations

Jan 11, 2014·Applied Microbiology and Biotechnology·Jonathan WilliamsKeith Baronian
May 15, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mamdouh S MasoudGehan S Elasala
May 13, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Samy M El-MegharbelMoamen S Refat

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