Synthesis, cytotoxicity and apoptosis of naphthalimide polyamine conjugates as antitumor agents

European Journal of Medicinal Chemistry
Zhi-yong TianChao-jie Wang

Abstract

Several naphthalimide polyamine conjugates were synthesized and evaluated for in vitro cytotoxicity against human leukemia K562, murine melanoma B16, Chinese hamster ovary CHO cell lines. Both triamine moieties and the length of spacers were crucial in elevating the potency of 1,8-naphthalimide. The typical compounds 5a and 5d exhibited excellent cell selectivity to cancer cells through the human hepatoma BEL-7402 and human normal hepatocyte QSG-7701 screens. In addition, 5d could disturb the cell cycle in B16 cells. The research on caspase activity and cytochrome c indicated that 5d could induce B16 cell apoptosis via both the mitochondrial and membrane death receptor pathways, and the Bcl-2 family numbers were involved in the control of apoptosis.

Citations

Sep 3, 2010·Apoptosis : an International Journal on Programmed Cell Death·Song-qiang XieChao-jie Wang
Mar 8, 2012·Apoptosis : an International Journal on Programmed Cell Death·Song-qiang XieChao-jie Wang
Aug 16, 2011·Cell Biology and Toxicology·Charles Stuart BestwickSusan J Duthie
May 4, 2013·Molecular Biology Reports·Robert SeligaJan Mojzis
Mar 21, 2012·Journal of Medicinal Chemistry·Yuxia WangChaojie Wang
Jan 5, 2011·Journal of Experimental & Clinical Cancer Research : CR·Asama MukherjeeUtpal Sanyal
Jul 1, 2014·Journal of Photochemistry and Photobiology. B, Biology·Zhiyong TianChaojie Wang
Jun 12, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhi-Yong TianChao-Jie Wang
Sep 18, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhi-Yong TianChao-Jie Wang
Jul 20, 2010·Expert Opinion on Drug Delivery·Songqiang XieChaojie Wang
Mar 2, 2016·Journal of Photochemistry and Photobiology. B, Biology·Zhiyong TianChaojie Wang
Feb 26, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lianhe YangChaojie Wang
Jul 6, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lin-Song WangYi-Fan Wang
Sep 5, 2012·The Journal of Pharmacy and Pharmacology·Song-Qiang XieChao-Jie Wang
Dec 22, 2014·Journal of Photochemistry and Photobiology. B, Biology·Zhiyong TianChaojie Wang
May 29, 2016·European Journal of Medicinal Chemistry·Qian LiChaojie Wang
May 11, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Aiten M SolimanMostafa Ghorab
Nov 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mei-Xia ZhaoChao-Jie Wang
Dec 6, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ming LiYingliang Wu
Mar 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chaochao GeChaojie Wang
Nov 17, 2020·Bioorganic & Medicinal Chemistry Letters·Manoj ManickamSang-Hun Jung
Apr 10, 2021·Bioorganic Chemistry·Paula CostalesJavier González-Sabín
Oct 12, 2010·Bioorganic & Medicinal Chemistry Letters·Jianhong WangChaojie Wang

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