Synthesis, cytotoxicity assessment, and interaction and docking of novel palladium(II) complexes of imidazole derivatives with human serum albumin

Journal of Biomolecular Structure & Dynamics
Mahboube Eslami MoghadamA A Saboury

Abstract

Imidazole analogs are the agents that attract both bioinorganic chemist and drug designer. Numerous methods have been proposed for synthesis of imidazole derivatives. In this study, a series of heterocyclic system with p-conjugated system such as 2-aryl-imidazo[4,5-f][1,10]phenanthroline analogs were synthesized. Then, three new palladium(II) complexes containing 2-(Furan-2-yl)-1H-Imidazo[4,5-f][1,10]Phenanthroline (FIP) and 2-(thiophen-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline (TIP) ligands were synthesized. The structures of the compounds, [Pd(Phen)(TIP)](NO3)2, [Pd(Phen)(FIP)](NO3)2, and [Pd(FIP)2]Cl were determined by spectroscopic methods and elemental analysis. Biological activity of the complexes synthesized was assessed against chronic myelogenous leukemia cell line, K562. Also, the interactions of human serum albumin with complexes were investigated using isothermal titration in the Tris buffer, pH 7.4. According to the results obtained, it was found that there is a set of six binding sites for these complexes on HSA with positive cooperativity in the binding process. Docking technique was also applied to confirm the experimental results. The results showed that smaller complexes have higher interaction affinity.

References

Jun 7, 2002·Critical Reviews in Oncology/hematology·Bernard Desoize, Claudie Madoulet
Jan 1, 2008·Bioorganic & Medicinal Chemistry Letters·Cenzo CongiuValentina Onnis
Apr 20, 2010·European Journal of Medicinal Chemistry·Hanan M Refaat
Jun 19, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Hassan Mansouri-TorshiziAli Akbar Saboury
May 15, 2012·Pharmacological Reports : PR·Agata JaszczyszynBogusława Czarnik-Matusewicz
May 29, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Jinhua ZhuXiuhua Liu
Jul 4, 2012·The Journal of Infection·Margarita SalvadóJuan Pablo Horcajada
Jul 24, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Icaro P CarusoMarinônio L Cornélio
Jan 9, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Ivonne LammersCees Gooijer
Sep 30, 2014·Combinatorial Chemistry & High Throughput Screening·Mahboube Eslami MoghadamMaryam Ghadamgahi

❮ Previous
Next ❯

Citations

May 25, 2016·Luminescence : the Journal of Biological and Chemical Luminescence·Javeed Ahmad WarSavitri Devi Srivastava
Apr 26, 2016·Journal of Biomolecular Structure & Dynamics·Laxmi N JattinagoudarShivamurti A Chimatadar
Feb 6, 2017·Journal of Biomolecular Structure & Dynamics·Roohollah GhobadiAli Akbar Saboury
Mar 25, 2017·Journal of Biomolecular Structure & Dynamics·Fatemeh Safa Shams AbyanehAdeleh Divsalar
Jan 29, 2018·Environmental Science and Pollution Research International·Sajedeh Tehrani NejadZeynab Khazaee
Aug 17, 2017·Journal of Biomolecular Structure & Dynamics·Somaye Shahraki, Ali Heydari
Oct 14, 2017·Journal of Biomolecular Structure & Dynamics·Sara Hadian RasananiMajid Amiri
Feb 16, 2019·Journal of Biomolecular Structure & Dynamics·Omid AbazariRoohollah Ghobadi
Jun 18, 2019·Journal of Biomolecular Structure & Dynamics·Soudeh HosseinzadehAshraf S Shahvelayati
Jan 27, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Nadali RamezaniSamaneh Zolghadri
Feb 23, 2021·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Nadali RamezaniMahdi Behzad

❮ Previous
Next ❯

Methods Mentioned

BETA
isothermal titration

Software Mentioned

HyperChem
AutoDock
AutoGrid
AutoDock Tool
AutoTors
GROMACS
Eureka

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.