Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes

European Journal of Medicinal Chemistry
Yun-Jun LiuFu-Hai Wu

Abstract

Two new ligands maip (1a), paip (1b) with their ruthenium (II) complexes [Ru(bpy)(2)(maip)](ClO(4))(2) (2a) and [Ru(bpy)(2)(paip)](ClO(4))(2) (2b) have been synthesized and characterized. The results show that complexes 2a and 2b interact with DNA through intercalative mode. The cytotoxicity of these compounds has been evaluated by MTT assay. The experiments on antioxidant activity show that these compounds exhibit good antioxidant activity against hydroxyl radical (OH).

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Citations

Nov 2, 2013·Journal of Photochemistry and Photobiology. B, Biology·Guang-Bin JiangYun-Jun Liu
Apr 28, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Yun-Jun LiuFu-Hai Wu
Mar 14, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·K EsmailzadehZ Sharifi
Oct 2, 2015·International Journal of Biological Macromolecules·Sreekanth ThotaEliezer J Barreiro
Apr 28, 2012·Journal of Biochemical and Molecular Toxicology·Ruina HuoFengling Cui
Nov 7, 2016·Journal of Photochemistry and Photobiology. B, Biology·Dan WanYun-Jun Liu
Nov 4, 2017·Chemical Communications : Chem Comm·Pingyu ZhangHui Chao
Nov 1, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Li-Feng TanXiao-Nan Sun
Jul 13, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Nancherla DeepikaSirasani Satyanarayana
Oct 1, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Xiangwen LiaoMingpei Liu
Feb 24, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Lifeng TanChao Weng
Sep 27, 2016·Journal of Inorganic Biochemistry·Wen-Xiu ChenZong-Wan Mao
Aug 27, 2021·Journal of Inorganic Biochemistry·Yuanyuan ZhangYunjun Liu

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