Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring

European Journal of Medicinal Chemistry
A K Mohammed IqbalImitiyaz Ahmed M Khazi

Abstract

Novel thiazolidinedione derivatives were synthesized by incorporating pharmacologically significant heterocycles viz, substituted thiazole, triazole, and oxadiazole moieties linked to the central phenyl ring via heteroatomlinkage with one/two carbon spacer as the structural analogs of Pioglitazone by employing multistep synthetic protocols. Structures of all the newly synthesized intermediates and target molecules were established by analytical and spectral data. These newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activities in male wistar rats. Some of the synthesized compounds demonstrated good activity.

Citations

Nov 30, 2013·European Journal of Medicinal Chemistry·Lingaiah NagarapuJagadesh Nanubolu
Aug 16, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Florentina Geanina LupascuLenuta Profire
Nov 2, 2013·European Journal of Medicinal Chemistry·Misael FerreiraMarcus Mandolesi Sá
May 15, 2013·Expert Opinion on Therapeutic Patents·Afshin Zarghi, Zahra Hajimahdi
Aug 29, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cledualdo Soares de OliveiraPetrônio Filgueiras de Athayde-Filho
Sep 14, 2019·Future Medicinal Chemistry·Mehmet Gümüşİrfan Koca
Oct 30, 2019·Mini Reviews in Medicinal Chemistry·Navjot Singh SethiRajesh K Singh
Apr 29, 2016·Chemistry, an Asian Journal·Raj KamalRavinder Kumar

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