Synthesis, In silico and In vitro Analysis of Hydrazones as Potential Antituberculosis Agents.

Current Computer-aided Drug Design
Bapu R ThoratRamesh S Yamgar

Abstract

Tuberculosis (TB) is a major cause of mortality and illness as reported by the W.H.O in 2019. The WHO report also mentioned the fact that about 10.0 million people fell ill with tuberculosis in the year 2018. Hydrazide-hydrazones having azomethine group (-NH-N=CH-) connected with carbonyl group is reported for the number of bioactivities like anti-inflammatory, anticonvulsant, anticancer, antiviral and antiprotozoal. The objective of our current study is to design and synthesise more potent hydrazide- hydrazones, containing anti-tubercular agents. In the current study, we synthesized 10 hydrazones (3a-3j) by stirring corresponding benzohydrazides (2) with substituted aldehydes (1a-j) in ethanol as a solvent and acetic acid as a catalyst at room temperature. All synthesized compounds were characterized by various spectroscopic techniques including elemental analysis, ultraviolet-visible spectroscopy, fluorescence, fourier- transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. Compounds (3a-3j) were tested for in vitro anti-TB activity using Microplate Alamar Blue Assay (MABA). All our synthesized compounds (3a-3j) were found to be potent against Mycobacteria tuberculosis (H37RV strain) with MIC (minimum in...Continue Reading

Citations

Mar 20, 2020·Combinatorial Chemistry & High Throughput Screening·Marcel L AlmeidaMarina G R Pitta
Nov 12, 2020·Natural Products and Bioprospecting·Atul R ChopadeSuraj N Mali

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