Synthesis of β-Arylethenesulfonyl Fluoride via Pd-Catalyzed Nondirected C-H Alkenylation

Organic Letters
Xiao-Yue ChenJin-Quan Yu

Abstract

A rapid synthesis of β-arylethenesulfonyl fluorides is realized using ligand-accelerated Pd(II)-catalyzed nondirected C-H alkenylation of simple arenes. The newly developed electron-deficient 2-pyridone ligand is crucial for this transformation with arenes as limiting reagent. This protocol features a broad substrate scope and good functional group tolerance. Late-stage functionalization of various pharmaceuticals and their further click manipulations demonstrate this procedure to be highly valuable.

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Citations

Aug 1, 2019·Chemical Society Reviews·A S BarrowJ E Moses
Feb 1, 2020·Chemistry : a European Journal·Ashot GevorgyanAnnette Bayer
Apr 7, 2020·Angewandte Chemie·Kiron Kumar GhoshManuel van Gemmeren
Aug 23, 2019·Nature Communications·Ruting XuSaihu Liao

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