Synthesis of (±)-Merrilactone A by a Desymmetrization Strategy

Chemistry : a European Journal
Wentan Liu, Bo Wang

Abstract

A concise synthesis of (±)-merrilactone A has been accomplished featuring desymmetrization of a Cs -symmetric dilactone, RhI -catalyzed intramolecular hydroacylation of a 4-alkynal, and TiIII -mediated reductive radical cyclization of epoxy-allene.

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Citations

Oct 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qili LuKyeong Lee
Feb 19, 2021·Journal of the American Chemical Society·Yang ShenYandong Zhang
Mar 12, 2021·Accounts of Chemical Research·Alison J Frontier, Paul P Sinclair
Dec 12, 2018·The Journal of Organic Chemistry·Matthew L CondakesThomas J Maimone
Jan 31, 2019·Journal of the American Chemical Society·Kevin HungThomas J Maimone
Aug 14, 2019·Journal of the American Chemical Society·Alexander S Burns, Scott D Rychnovsky

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