Synthesis of (+)-Vitepyrroloid A and (+)-Vitepyrroloid B by Late-Stage Ni-Catalyzed C(sp2)-C(sp3) Cross-Electrophile Coupling

The Journal of Organic Chemistry
Martina MengerMathias Christmann

Abstract

A concise and scalable five-step synthesis of vitepyrroloids A and B, two cytotoxic labdane diterpenoid alkaloids from Vitex trifolia, is reported. The presented approach features a Ni-catalyzed cross-electrophile coupling between a (+)-sclareolide-derived alkyl iodide and 3-bromo-2-cyanopyrrole.

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Citations

Jul 14, 2021·The Journal of Organic Chemistry·Gregory L BeutnerSteven R Wisniewski
Jul 8, 2021·Chemistry : a European Journal·Ana L AguirreYing Wang

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