PMID: 11606139Oct 19, 2001Paper

Synthesis of 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole analogues as novel antiplatelet agents

Journal of Medicinal Chemistry
F Y LeeS C Kuo

Abstract

1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (28, YC-1) was selected as the lead compound for systemic structural modification. After screening for antiplatelet activity, SARs of YC-1 analogues were established. Among these potent active derivatives, compounds 29, 30, 31, 44, and 45 functioned as potent activators of sGC and inhibitors of PDE5 with potency comparable to that of YC-1. In addition, compound 58 was found to be a selective and potent inhibitor of protease-activated receptor type 4 (PAR4)-dependent platelet activation.

References

Jan 28, 1998·Molecular Pharmacology·A Friebe, D Koesling
Jan 28, 1999·Biochemical and Biophysical Research Communications·V S SharmaD Koesling

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Citations

Sep 7, 2006·Nature Reviews. Drug Discovery·Oleg V EvgenovJohannes-Peter Stasch
Feb 5, 2016·British Journal of Pharmacology·Shauna L French, Justin R Hamilton
Sep 14, 2016·Annual Review of Pharmacology and Toxicology·Justin R Hamilton, JoAnn Trejo
Mar 4, 2017·Bioorganic & Medicinal Chemistry Letters·Shinde VidyacharanDuddu S Sharada
Jul 26, 2003·Circulation Research·Andreas Friebe, Doris Koesling
Apr 28, 2007·Chemical Biology & Drug Design·Dariusz PlewczynskiLeszek Rychewski
Jun 21, 2017·Future Medicinal Chemistry·Oscar BenimanaZhouling Xie
May 16, 2014·Acta Crystallographica. Section E, Structure Reports Online·Assoman KouakouLahcen El Ammari
Nov 26, 2015·Acta Crystallographica. Section E, Crystallographic Communications·Assoman KouakouLahcen El Ammari
Nov 26, 2015·Acta Crystallographica. Section E, Crystallographic Communications·Mohammed BoulhaouaLahcen El Ammari
Dec 12, 2017·Organic & Biomolecular Chemistry·Ying YangZhuang-Ping Zhan
Jul 22, 2021·The Journal of Organic Chemistry·Suvam BhattacharjeeAlakananda Hajra
Jul 27, 2021·The Journal of Organic Chemistry·Payel Ghosh, Alakananda Hajra
Oct 17, 2019·The Journal of Organic Chemistry·Amrita Dey, Alakananda Hajra
Mar 16, 2019·The Journal of Organic Chemistry·Mukta SingsardarAlakananda Hajra
May 24, 2019·The Journal of Organic Chemistry·Arumugavel MuruganDuddu S Sharada
Aug 29, 2019·ACS Omega·Payel GhoshAlakananda Hajra
Jun 28, 2019·Journal of Medicinal Chemistry·Michael M MillerAnne Marinier
Oct 23, 2018·The Journal of Organic Chemistry·Payel GhoshAlakananda Hajra
Feb 27, 2015·Organic Letters·Daniel C SchmittRobert E Kyne

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