PMID: 2489031Jan 1, 1989Paper

Synthesis of 11-aminomethyl-2,6-dimethyl-3,9-diisopropyl-tricyclo [5.3.2.0(1.5)] dodeca-5,9-dien-8-ol

Yao xue xue bao = Acta pharmaceutica Sinica
Y T Guo, X M Du

Abstract

Structural reconstruction from natural non-alkaloidal compounds might lead to new bioactivity. In this paper, the synthesis of one of such compounds--11-aminomethyl-2,6-dimethyl-3,9-diisopropyl-tricyclo [5.3.2.0(1.5)]dodeca-5, 9-dien-8-ol was reported. The compound was derived from curcumol via a tropone compound as an intermediate and was found to have an activity of markedly lowering blood pressure in anesthetized rats.

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